LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (C-Term) antibody

Antigen: LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1)

Synonyms: wts, WARTS, AW208599, LATS1, Lats, MGC123219, wu:fc19a11, zgc:123219, si:dkey-181i3.5, lats1

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350432

Additional Information

Alternative name: LATS1 (WARTS) (c-terminal)

Swiss-Prot: Q8BYR2

Immunogen: A synthetic peptide to the c-terminal of mouse LATS1 (WARTS) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Subcellular location: Centrosome, Spindle. Note: Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. Also known as: Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase.

Specificity: Appears to be specific for LATS1.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Tao, Zhang, Turenchalk et al.: "Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity." in: Nature genetics, Vol. 21, Issue 2, pp. 177-81, 1999 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Di Betta, Mittempergher, Nascimbeni et al.: "Outcome of duodenal switch with a transitory vertical gastroplasty, in super-super-obese patients in an 8-year series." in: Obesity surgery, Vol. 18, Issue 2, pp. 182-6, 2008 (PubMed).

Trost, English, Lemieux et al.: "The phagosomal proteome in interferon-gamma-activated macrophages." in: Immunity, Vol. 30, Issue 1, pp. 143-54, 2009 (PubMed).