LATS1 antibody (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila)) (C-Term)

Details for Product anti-LATS1 Antibody No. ABIN350432, Supplier: Log in to see
Antigen
  • Lats
  • si:dkey-181i3.5
  • wu:fc19a11
  • zgc:123219
  • lats1
  • AW208599
  • WARTS
  • wts
  • RGD1564085
  • LATS, large tumor suppressor, homolog 1 (Drosophila)
  • LATS, large tumor suppressor, homolog 1
  • large tumor suppressor
  • large tumor suppressor kinase 1
  • LATS1
  • lats1
  • TEgg117h14.1
  • Lats1
Alternatives
anti-Rat (Rattus) LATS1 antibody for ELISA
Epitope
C-Term
19
16
15
11
3
3
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
77
59
57
4
3
3
2
2
2
1
1
1
1
Host
Rabbit
73
4
Clonality
Polyclonal
Conjugate
This LATS1 antibody is un-conjugated
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
45
26
25
19
12
3
1
1
Options
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Immunogen A synthetic peptide to the c-terminal of mouse LATS1 (WARTS) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for LATS1.
Purification Whole serum
Alternative Name LATS1 (LATS1 Antibody Abstract)
Target Type Tag
Background Function: Tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Subcellular location: Centrosome, Spindle. Note: Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. Also known as: Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase.
Research Area Cancer, Apoptosis/Necrosis, Kinases/Phosphatases
Pathways Regulation of Actin Filament Polymerization, Maintenance of Protein Location
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Trost, English, Lemieux, Courcelles, Desjardins, Thibault: "The phagosomal proteome in interferon-gamma-activated macrophages." in: Immunity, Vol. 30, Issue 1, pp. 143-54, 2009 (PubMed).

Di Betta, Mittempergher, Nascimbeni, Salerni: "Outcome of duodenal switch with a transitory vertical gastroplasty, in super-super-obese patients in an 8-year series." in: Obesity surgery, Vol. 18, Issue 2, pp. 182-6, 2008 (PubMed).

Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Tao, Zhang, Turenchalk, Stewart, St John, Chen, Xu: "Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity." in: Nature genetics, Vol. 21, Issue 2, pp. 177-81, 1999 (PubMed).