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LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 5-50) antibody

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Synonyms 4932411G09Rik, AV277261, AW228608, KPM, lats2
AA 5-50
(12), (11), (9), (9), (8), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Mouse (Murine), Human
(53), (37), (15)
(65), (2)
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(44), (34), (27), (12), (8), (6), (3), (2), (2), (1)
Pubmed 5 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from aa region 5-50 of mouse LATS2 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for LATS2.
Purification Whole serum
Alternative Name LATS2 (LATS2 Antibody Abstract)
Background Function: Tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
Subcellular location: Centrosome. Cytoplasm. Note: Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.
Tissue specificity: Expressed at high levels in ovary and testis and at lower levels in all other tissues examined. Also known as: Serine/threonine-protein kinase LATS2, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Kinase phosphorylated during mitosis protein.
Research Area Signaling, DNA/RNA
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

McPherson, Tamblyn, Elia et al.: "Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity." in: The EMBO journal, Vol. 23, Issue 18, pp. 3677-88, 2004 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Yabuta, Fujii, Copeland et al.: "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts." in: Genomics, Vol. 63, Issue 2, pp. 263-70, 2000 (PubMed).

Catalog No. ABIN350433
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