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Details for Product No. ABIN350433

LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (N-Term) antibody

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Antigen
Synonyms KPM, AV277261, AW228608, 4932411G09Rik
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350433
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide to the n-terminal of mouse LATS2 conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for LATS2.
Purity whole serum
Alternative Name LATS2
Background Function: Tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
Subcellular location: Centrosome. Cytoplasm. Note: Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.
Tissue specificity: Expressed at high levels in ovary and testis and at lower levels in all other tissues examined. Also known as: Serine/threonine-protein kinase LATS2, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Kinase phosphorylated during mitosis protein.
UniProt Q7TSJ6
Application Notes IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Yabuta, Fujii, Copeland et al.: "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts." in: Genomics, Vol. 63, Issue 2, pp. 263-70, 2000 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

McPherson, Tamblyn, Elia et al.: "Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity." in: The EMBO journal, Vol. 23, Issue 18, pp. 3677-88, 2004 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Alternatives for antigen "LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2)", type "Antibodies"
Hosts (43), (2)
Reactivities (43), (35), (24), (24), (24), (12), (12)
Applications (23), (20), (19), (9), (8), (3), (3), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (13), (2), (2), (2), (1), (1), (1), (1)
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