Add to Basket
|+1 404 474 4654|
|+1 888 205 9894 (TF)|
LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (N-Term) antibody
|Synonyms||KPM, FLJ13161, AV277261, AW228608, 4932411G09Rik|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide to the n-terminal of mouse LATS2 conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||FUNCTION: Tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Subcellular location: Centrosome. Cytoplasm. Note: Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Tissue specificity: Expressed at high levels in ovary and testis and at lower levels in all other tissues examined. Also known as: Serine/threonine-protein kinase LATS2, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Kinase phosphorylated during mitosis protein.|
|Specificity||Appears to be specific for LATS2.|
|Application Notes||IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Yabuta, Fujii, Copeland et al.: "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts." in: Genomics, Vol. 63, Issue 2, pp. 263-70, 2000 (PubMed).
Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).
McPherson, Tamblyn, Elia et al.: "Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity." in: The EMBO journal, Vol. 23, Issue 18, pp. 3677-88, 2004 (PubMed).
Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).
Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).
|Reactivities||Human (31), Mouse (Murine) (27), Cow (Bovine) (25), Dog (Canine) (25), Rat (Rattus) (25), Horse (Equine) (24), Chicken (20), Pig (Porcine) (5), Cat (Feline) (1)|
|Applications||Immunofluorescence (IF) (23), ELISA (9), Western Blotting (WB) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunohistochemistry (IHC) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)|
|Epitopes||pSer83 (4), Center (1), Internal Region (1), pThr345 (1)|