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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Microtubule Associated Protein 2 (MAP2) antibody
|Synonyms||MAP2A, MAP2B, MAP2C, DKFZp686I2148, MAP2, MAP-2, Mtap-2, xmap2, MGC53131, a730034c02, map2, MGC145864|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|8 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||MAP2 (Microtubule-associated protein 2, MAP-2, MAP 2, MAP2R)|
|Immunogen||A synthetic peptide from human MAP2 (Microtubule-associated protein 2, MAP-2, MAP 2, MAP2R) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||Regulates and organizes microtubules; may serve as a scaffolding protein for neuromodulatory activities. FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. DEVELOPMENTAL STAGE: Isoform MAP2C is expressed during embryonic brain development and until postanatal day 10. Isoform MAP2B is expressed throughout brain development. Also known as: Microtubule-associated protein 2, MAP 2, MAP-2, MAP2R.|
|Specificity||Appears to be specific for MAP-2.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Kosik, Orecchio, Bakalis et al.: "Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles." in: Journal of neurochemistry, Vol. 51, Issue 2, pp. 587-98, 1988 (PubMed).
Dammerman, Yen, Shafit-Zagardo: "Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles." in: Journal of neuroscience research, Vol. 24, Issue 4, pp. 487-95, 1990 (PubMed).
Albala, Kalcheva, Shafit-Zagardo: "Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2)." in: Gene, Vol. 136, Issue 1-2, pp. 377-8, 1994 (PubMed).
DeGiorgis, Jaffe, Moreira et al.: "Phosphoproteomic analysis of synaptosomes from human cerebral cortex." in: Journal of proteome research, Vol. 4, Issue 2, pp. 306-15, 2005 (PubMed).
Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).
Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).
Cantin, Yi, Lu et al.: "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." in: Journal of proteome research, Vol. 7, Issue 3, pp. 1346-51, 2008 (PubMed).
|Hosts||Mouse (10), Rabbit (3)|
|Reactivities||Human (11), Mouse (Murine) (11), Pig (Porcine) (10), Cow (Bovine) (7), Cat (Feline) (6), Rat (Rattus) (1)|
|Applications||Western Blotting (WB) (13), Immunocytochemistry (ICC) (10), Immunoprecipitation (IP) (10), ELISA (4), Immunohistochemistry (Frozen Sections) (IHC (fro)) (4), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (IHC) (3), Radioimmunoassay (RIA) (2)|
|Conjugates||DyLight 549 (2), Dyomics 547 (2)|