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Details for Product No. ABIN350442

MAS-Related GPR, Member D (MRGPRD) (4th Cytoplasmic Loop) antibody

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Antigen
Synonyms MRGD, TGR7, Gm499, MrgD, Mrgd
Epitope
»Alternatives 4th Cytoplasmic Loop
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN350442
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic loop of mouse Mas-related G-protein coupled receptor member D (MRGPRD) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 81% identity with rat's sequence.
Specificity Appears to be specific for MRGPRD.
Purity whole serum
Alternative Name Mas-related G-protein coupled receptor member D (MRGPRD)
Background Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
Subcellular location: Cell membrane, Multi-pass membrane protein. Note: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. Also known as: Mas-related G-protein coupled receptor, member D, Beta-alanine receptor, G-protein coupled receptor TGR7, MRGD, MRGPRD.
UniProt Q91ZB8
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Dong, Han, Zylka et al.: "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons." in: Cell, Vol. 106, Issue 5, pp. 619-32, 2001 (PubMed).

Shinohara, Harada, Ogi et al.: "Identification of a G protein-coupled receptor specifically responsive to beta-alanine." in: The Journal of biological chemistry, Vol. 279, Issue 22, pp. 23559-64, 2004 (PubMed).

Alternatives for antigen "MAS-Related GPR, Member D (MRGPRD)", type "Antibodies"
Hosts (13)
Reactivities (12), (1)
Applications (11), (2), (2)
Epitopes (4), (2), (1), (1), (1)
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