MAS-Related GPR, Member D (MRGPRD) (AA 270-320) antibody

Details for Product No. ABIN350442
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Antigen
Synonyms MRGD, TGR7, Gm499, MrgD, Mrgd
Epitope
AA 270-320
(4), (2), (1), (1), (1)
Reactivity
Mouse (Murine)
(11), (1)
Host
Rabbit
(12)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(10), (2), (2), (2)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN350442
454.67 $
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Immunogen A synthetic peptide from aa region 270-320 of mouse MRGPRD conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 81% identity with rat's sequence.
Specificity Specific for MRGPRD.
Purification Whole serum
Alternative Name MRGPRD
Background Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
Subcellular location: Cell membrane, Multi-pass membrane protein. Note: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. Also known as: Mas-related G-protein coupled receptor, member D, Beta-alanine receptor, G-protein coupled receptor TGR7, MRGD, MRGPRD.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Dong, Han, Zylka et al.: "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons." in: Cell, Vol. 106, Issue 5, pp. 619-32, 2001 (PubMed).

Shinohara, Harada, Ogi et al.: "Identification of a G protein-coupled receptor specifically responsive to beta-alanine." in: The Journal of biological chemistry, Vol. 279, Issue 22, pp. 23559-64, 2004 (PubMed).

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