MAS-Related GPR, Member D (MRGPRD) (AA 270-320) antibody

Details for Product No. ABIN350442
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Antigen
Synonyms MRGD, TGR7, Gm499, MrgD, Mrgd
Epitope
AA 270-320
(4), (2), (1), (1), (1)
Reactivity
Human
(12)
Host
Rabbit
(12)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(10), (2), (2)
Pubmed 2 references available
Catalog no. ABIN350442
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from AA 270-320 of mouse MRGPRD conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 81% identity with rat's sequence.
Specificity Specific for VN1R5.
Purification whole serum
Alternative Name Mas-related G-protein coupled receptor member D (MRGPRD)
Background Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
Subcellular location: Cell membrane, Multi-pass membrane protein. Note: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. Also known as: Mas-related G-protein coupled receptor, member D, Beta-alanine receptor, G-protein coupled receptor TGR7, MRGD, MRGPRD.
UniProt Q7Z5H4
Research Area Signaling
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Dong, Han, Zylka et al.: "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons." in: Cell, Vol. 106, Issue 5, pp. 619-32, 2001 (PubMed).

Shinohara, Harada, Ogi et al.: "Identification of a G protein-coupled receptor specifically responsive to beta-alanine." in: The Journal of biological chemistry, Vol. 279, Issue 22, pp. 23559-64, 2004 (PubMed).

Hosts (12)
Reactivities (12)
Applications (10), (2), (2)
Epitopes (4), (2), (1), (1), (1)
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