MAS-Related GPR, Member D (MRGPRD) antibody

Antigen: MAS-Related GPR, Member D (MRGPRD)

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350443

Additional Information

Alternative name: Mas-related G-protein coupled receptor member D (MRGPRD, GPCR TGR7)

Swiss-Prot: Q7TN41

Immunogen: A synthetic peptide from the 3d cytoplasmic loop of rat Mas-related G-protein coupled receptor member D (MRGPRD, GPCR TGR7) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Co-expressed in the small diameter neurons with P2X3 and VR1 in dorsal root ganglia. Also known as: MRGPRD, beta-alanine receptor, G-protein coupled receptor TGR7, Mrgd, MAS-related GPR, member D.

Specificity: Appears to be specific for MRGPRD.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Zylka, Dong, Southwell et al.: "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 17, pp. 10043-8, 2003 (PubMed).

Shinohara, Harada, Ogi et al.: "Identification of a G protein-coupled receptor specifically responsive to beta-alanine." in: The Journal of biological chemistry, Vol. 279, Issue 22, pp. 23559-64, 2004 (PubMed).