MAS-Related GPR, Member D (MRGPRD) antibody

Details for Product No. ABIN350443
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Antigen
Synonyms MRGD, TGR7, Gm499, MrgD, Mrgd
Reactivity
Rat (Rattus)
(11), (1)
Host
Rabbit
(12)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(10), (2), (2)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN350443
454.67 $
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Immunogen A synthetic peptide from rat Mas-related G-protein coupled receptor member D (MRGPRD, GPCR TGR7) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for MRGPRD.
Purification Whole serum
Alternative Name MRGPRD
Background Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i).
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Co-expressed in the small diameter neurons with P2X3 and VR1 in dorsal root ganglia. Also known as: MRGPRD, beta-alanine receptor, G-protein coupled receptor TGR7, Mrgd, MAS-related GPR, member D.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Zylka, Dong, Southwell et al.: "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 17, pp. 10043-8, 2003 (PubMed).

Shinohara, Harada, Ogi et al.: "Identification of a G protein-coupled receptor specifically responsive to beta-alanine." in: The Journal of biological chemistry, Vol. 279, Issue 22, pp. 23559-64, 2004 (PubMed).

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