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Mature BDNF (N-Term) antibody

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Human, Rat (Rattus), Mouse (Murine)
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Immunohistochemistry (IHC), Western Blotting (WB)
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Pubmed 7 references available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from n-terminal region of human mature BDNF (Brain derived neurotrophic factor) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many other species including rat, mouse, zebra fish and xenopus.
Specificity Specific for mature BDNF.
Purification Affinity purified
Background Function: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Subunit: Monomers and homodimers. Binds to NTRK2/TRKB.
Subcellular location: Secreted. Also known as: Brain-derived neurotrophic factor, BDNF, Abrineurin.
Application Notes A concentration of 1-5 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Aid, Kazantseva, Piirsoo et al.: "Mouse and rat BDNF gene structure and expression revisited." in: Journal of neuroscience research, Vol. 85, Issue 3, pp. 525-35, 2007 (PubMed).

Liu, Lu, Zhu et al.: "Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine." in: Brain research, Vol. 1067, Issue 1, pp. 1-12, 2006 (PubMed).

Timmusk, Palm, Metsis et al.: "Multiple promoters direct tissue-specific expression of the rat BDNF gene." in: Neuron, Vol. 10, Issue 3, pp. 475-89, 1993 (PubMed).

Hallboeoek, Ibuaunez, Persson: "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary." in: Neuron, Vol. 6, Issue 5, pp. 845-58, 1991 (PubMed).

Yancopoulos, Maisonpierre, Ip et al.: "Neurotrophic factors, their receptors, and the signal transduction pathways they activate." in: Cold Spring Harbor symposia on quantitative biology, Vol. 55, pp. 371-9, 1992 (PubMed).

Maisonpierre, Le Beau, Espinosa et al.: "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations." in: Genomics, Vol. 10, Issue 3, pp. 558-68, 1991 (PubMed).

Ohara, Gahara, Teraoka et al.: "A rat brain-derived neurotrophic factor-encoding gene generates multiple transcripts through alternative use of 5' exons and polyadenylation sites." in: Gene, Vol. 121, Issue 2, pp. 383-6, 1992 (PubMed).

Catalog No. ABIN350452
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