Neurotrophin 3 (NTF3) antibody

Antigen: Neurotrophin 3 (NTF3)

Synonyms: NT3, HDNF, NGF2, NGF-2, MGC129711, NT-3, ntf3-pen, wu:fl98d04, nt3, hdnf, ngf2, nt-3, ngf-2, MGC84157, NTF3

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350457

Additional Information

Alternative name: mature NT-3 (Neurotrophin-3)

Swiss-Prot: P20783

Immunogen: A synthetic peptide from mature human NT3 (Neurotrophin-3, NT-3) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in many other species including rat and mouse.

Format: Lyophilized

Description: FUNCTION: Seems to promotes the survival of visceral and proprioceptive sensory neurons. Tissue specificity: Brain and peripheral tissues. SUBCELLULAR LOCATION: Secreted. Also known as: Neurotrophin-3, HDNF, Nerve growth factor 2, NGF-2, NTF3.

Specificity: Appears to be specific for mature NT-3.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Hallboeoek, Ibuaunez, Persson: "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary." in: Neuron, Vol. 6, Issue 5, pp. 845-58, 1991 (PubMed).

Jones, Reichardt: "Molecular cloning of a human gene that is a member of the nerve growth factor family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 20, pp. 8060-4, 1990 (PubMed).

Rosenthal, Goeddel, Nguyen et al.: "Primary structure and biological activity of a novel human neurotrophic factor." in: Neuron, Vol. 4, Issue 5, pp. 767-73, 1990 (PubMed).

Kaisho, Yoshimura, Nakahama: "Cloning and expression of a cDNA encoding a novel human neurotrophic factor." in: FEBS letters, Vol. 266, Issue 1-2, pp. 187-91, 1990 (PubMed).

Robinson, Radziejewski, Stuart et al.: "Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer." in: Biochemistry, Vol. 34, Issue 13, pp. 4139-46, 1995 (PubMed).