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Opsin 4 (OPN4) (AA 420-470) antibody

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Synonyms opn4, opn4l, opn4m2, OPN4-2, cOpn4L, melanopsin, opn4-A, Xmop, opn4d, MOP, 1110007J02Rik, Gm533
AA 420-470
(8), (1), (1), (1), (1), (1)
(15), (2), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(17), (9), (4), (3), (1)
Pubmed 5 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from aa region 420-470 of human melanopsin conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for Melanopsin.
Purification Whole serum
Alternative Name Melanopsin (OPN4 Antibody Abstract)
Background Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.
Function: Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal.
Subcellular location: Membrane, Multi-pass membrane protein. Note: Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells .
Tissue specificity: Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina. Also known as: Melanopsin, opsin-4, OPN4, MOP, OPN 4, MGC142118.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Kumbalasiri, Rollag, Isoldi et al.: "Melanopsin triggers the release of internal calcium stores in response to light." in: Photochemistry and photobiology, Vol. 83, Issue 2, pp. 273-9, 2007 (PubMed).

Dacey, Liao, Peterson et al.: "Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN." in: Nature, Vol. 433, Issue 7027, pp. 749-54, 2005 (PubMed).

Melyan, Tarttelin, Bellingham et al.: "Addition of human melanopsin renders mammalian cells photoresponsive." in: Nature, Vol. 433, Issue 7027, pp. 741-5, 2005 (PubMed).

Qiu, Kumbalasiri, Carlson et al.: "Induction of photosensitivity by heterologous expression of melanopsin." in: Nature, Vol. 433, Issue 7027, pp. 745-9, 2005 (PubMed).

Provencio, Rodriguez, Jiang et al.: "A novel human opsin in the inner retina." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 2, pp. 600-5, 2000 (PubMed).

Catalog No. ABIN350459
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