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Details for Product No. ABIN350466

Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) antibody

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Antigen
Synonyms ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, Map1lc3, Mpl3, zbs559, 1010001C15Rik, Atg8, LC3b, zgc:56434, wu:fb60g11, map1lc3b, MGC76283, MAP1LC3B
Reactivity
»Alternatives Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350466
Quantity 150 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of human, chicken microtubule-associated proteins 1A/1B light chain 3B (MAP1A/MAP1B LC3 B, Map1lc3b) conjugated to an immunogenic carrier protein has been used as the immunogen.
Specificity Appears to be specific for MAP1LC3B.
Purification The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Purity whole serum
Alternative Name microtubule-associated protein 1 light chain 3 beta (MAP1A/MAP1B LC3 B, Map1lc3b)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene inautophagy, a process that involves the bulk degradation of cytoplasmic component.
Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes). May mediate MAPlA and MAPlB microtubule binding activity during development of the nervous system
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.
Subcellular location: Cytoplasm. Intracytoplasmic membrane, Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane, Lipid-anchor.Note: LC3-II binds to the autophagic membranes. Also known as: MLP3B, Map1alc3, Map1lc3, Microtubule-associated protein 1 light chain 3 beta, MAP1A/MAP1B LC3 B, MAP1A/1B light chain 3 B, MAP1 light chain 3-like protein 2,autophagy-related protein LC3 B,autophagy-related ubiquitin-like modifier LC3 B, Mpl3, MGC93422.
Research Area Autophagy
Application Notes IHC, WB. Use at a dilution of 1 : 300 to 1 : 2000. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
He, Dang, Dai et al.: "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B." in: The Journal of biological chemistry, Vol. 278, Issue 31, pp. 29278-87, 2003 (PubMed).

Tanida, Ueno, Kominami: "Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes." in: The Journal of biological chemistry, Vol. 279, Issue 46, pp. 47704-10, 2004 (PubMed).

Wiemann, Arlt, Huber et al.: "From ORFeome to biology: a functional genomics pipeline." in: Genome research, Vol. 14, Issue 10B, pp. 2136-44, 2004 (PubMed).

Alternatives for antigen "Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B)", type "Antibodies"
Hosts (83), (13), (2)
Reactivities (95), (57), (42), (26), (26), (14), (13), (3), (2), (2), (1)
Applications (64), (29), (27), (26), (20), (19), (16), (13), (9), (8), (7), (1), (1)
Conjugates (6), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (17), (6), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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