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Mucolipin 1 (MCOLN1) (AA 150-210) antibody

Details for Product No. ABIN350481
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Antigen
Synonyms mcoln1, mcoln1.1, zgc:63619, mln1, mucolipin-1, MCOLN1, MG-2, ML4, MLIV, MST080, TRP-ML1, TRPM-L1, TRPML1, 2210015I05Rik, mucolipidin
Epitope
AA 150-210
(13), (7), (5), (3), (1), (1), (1)
Reactivity
Mouse (Murine)
(20), (9), (9), (1), (1)
Host
Rabbit
(19), (1), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(22), (9), (4), (2), (1)
Pubmed 5 references available
Quantity 100 µL
Options
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Catalog No. ABIN350481
454.67 $
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Immunogen A synthetic peptide from aa 150-210 of mouse Mucolipin 1 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for Mucolipin 1.
Purification Whole serum
Alternative Name Mucolipin 1
Background Polycystin cation channel contains the cation channel region of PKD1 and PKD2 proteins, pfam08016
Function: Cationic channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.
Subunit: Forms multimeric complexes.
Subcellular location: Cell membrane, Multi-pass membrane protein. Late endosome membrane, Multi-pass membrane protein. Lysosome membrane, Multi-pass membrane protein.
Tissue specificity: Widely expressed, with the highest expression in brain, liver and kidney.
Miscellaneous: Channel function is transiently modulated by changes in Ca(2+), and inhibited by a reduction of pH, pH changes modify the aggregation state of unitary channels. SIMILARITY: Belongs to the transient receptor family, polycystin subfamily. Also known as:Mucolipin-1, Mucolipidin, Mcoln1,Mucolipin 1, MCLN1, TRPML1, MGC7172, 2210015I05Rik.
Research Area Signaling
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Falardeau, Kennedy, Acierno et al.: "Cloning and characterization of the mouse Mcoln1 gene reveals an alternatively spliced transcript not seen in humans." in: BMC genomics, Vol. 3, Issue 1, pp. 3, 2003 (PubMed).

Ballif, Villén, Beausoleil et al.: "Phosphoproteomic analysis of the developing mouse brain." in: Molecular & cellular proteomics : MCP, Vol. 3, Issue 11, pp. 1093-101, 2004 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Lee, Xu, Chen et al.: "Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 4, pp. 669-76, 2007 (PubMed).

Validation Images
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