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Details for Product No. ABIN350481

Mucolipin 1 (Mcoln1, MCLN1,TRPML1) (N-Term) antibody

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Antigen
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350481
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal part of mouse Mucolipin 1 conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for Mucolipin 1.
Purification The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Purity whole serum
Background Polycystin cation channel contains the cation channel region of PKD1 and PKD2 proteins, pfam08016
Function: Cationic channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.
Subunit: Forms multimeric complexes.
Subcellular location: Cell membrane, Multi-pass membrane protein. Late endosome membrane, Multi-pass membrane protein. Lysosome membrane, Multi-pass membrane protein.
Tissue specificity: Widely expressed, with the highest expression in brain, liver and kidney.
Miscellaneous: Channel function is transiently modulated by changes in Ca(2+), and inhibited by a reduction of pH, pH changes modify the aggregation state of unitary channels. SIMILARITY: Belongs to the transient receptor family, polycystin subfamily. Also known as:Mucolipin-1, Mucolipidin, Mcoln1,Mucolipin 1, MCLN1, TRPML1, MGC7172, 2210015I05Rik.
UniProt Q99J21
Application Notes IHC, WB. A dilution of 1: 300 to 1: 3000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Falardeau, Kennedy, Acierno et al.: "Cloning and characterization of the mouse Mcoln1 gene reveals an alternatively spliced transcript not seen in humans." in: BMC genomics, Vol. 3, Issue 1, pp. 3, 2003 (PubMed).

Ballif, Villén, Beausoleil et al.: "Phosphoproteomic analysis of the developing mouse brain." in: Molecular & cellular proteomics : MCP, Vol. 3, Issue 11, pp. 1093-101, 2004 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Lee, Xu, Chen et al.: "Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 4, pp. 669-76, 2007 (PubMed).

Alternatives for antigen "Mucolipin 1 (Mcoln1, MCLN1,TRPML1)", type "Antibodies"
Hosts (1), (1)
Reactivities (2)
Applications (2), (2)
Epitopes (2)
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