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Mucolipin 3 (Mcoln3) (Internal Region) antibody

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Synonyms MCOLN3, 6720490O21Rik, TRPML3, Va, TRP-ML3, trp-ml3, trpml3
Internal Region
(17), (15), (7), (4), (4), (1), (1)
Mouse (Murine)
(35), (11), (10), (1), (1), (1), (1), (1), (1)
(37), (3), (2), (1)
(2), (2), (2), (2), (2), (2)
Immunohistochemistry (IHC), Western Blotting (WB)
(41), (17), (16), (1), (1)
Pubmed 2 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of mouse Mucolipin 3 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for Mucolipin 3.
Purification Whole serum
Alternative Name Mucolipin 3 (Mcoln3 Antibody Abstract)
Background SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein (Potential).
Tissue specificity: Expressed in the cochlea, particularly in the inner and outer hair cells. DISEASE: Defects in Mcoln3 are the cause of the varitin-waddler (Va) phenotype. Classical Va mice exhibit early-onset hearing loss, vestibular defects, pigmentation abnormalities and perinatal lethality. The phenotype varitin-waddler Jackcon (Va-J), which arose in a cross segregating for Va, is similar but less severe. SIMILARITY: Belongs to the transient receptor family, polycystin subfamily. Also known as: Mcoln3Mucolipin 3, Va, TRPML3, MGC124245, MGC124246, 6720490O21Rik.
Research Area Neurology, Metabolism
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Di Palma, Belyantseva, Kim et al.: "Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 23, pp. 14994-9, 2002 (PubMed).

Catalog No. ABIN350489
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