Mucolipin 3 (Mcoln3) (internal part) antibody

Antigen: Mucolipin 3 (Mcoln3)

Synonyms: Va, TRPML3, MGC124245, MGC124246, 6720490O21Rik, TRP-ML3, FLJ11006, FLJ36629, MGC71509, MGC80434, MCOLN3

Epitope: internal part

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350489

Additional Information

Alternative name: Mucolipin 3 (Mcoln3, MCLN3) (internal part)

Swiss-Prot: Q8R4F0

Immunogen: A synthetic peptide from the internla part of mouse Mucolipin 3 conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed in the cochlea; particularly in the inner and outer hair cells. DISEASE: Defects in Mcoln3 are the cause of the varitin-waddler (Va) phenotype. Classical Va mice exhibit early-onset hearing loss, vestibular defects, pigmentation abnormalities and perinatal lethality. The phenotype varitin-waddler Jackcon (Va-J), which arose in a cross segregating for Va, is similar but less severe. SIMILARITY: Belongs to the transient receptor family, polycystin subfamily. Also known as: Mcoln3Mucolipin 3, Va, TRPML3, MGC124245, MGC124246, 6720490O21Rik.

Specificity: Appears to be specific for Mucolipin 3.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 3000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Di Palma, Belyantseva, Kim et al.: "Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 23, pp. 14994-9, 2002 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).