Multiple PDZ Domain Protein (MPDZ) (AA 1400-1500) antibody

Details for Product No. ABIN350501
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Antigen
Synonyms HYC2, MUPP1, AI225843, B930003D11Rik
Epitope
AA 1400-1500
(1), (1), (1), (1), (1)
Reactivity
Hamster
(17), (13), (13), (12), (12)
Host
Sheep
(18)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(10), (6), (4), (4), (3)
Pubmed 5 references available
Catalog no. ABIN350501
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from AA 1400-1500 of human MUPP1 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Highly specific for mature olfactory neurons (including axon and terminals).
Purification The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
whole serum
Alternative Name Multiple PDZ domain protein (MPDZ, MUPP1)
Background Function: Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.
Subcellular location: Cell membrane, Peripheral membrane protein, Cytoplasmic side. Apical cell membrane, Peripheral membrane protein, Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, synapse. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Note:  Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells. In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.
Tissue specificity: Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Also known as: MPDZ, MUPP1, Multi PDZ domain protein 1, Multi-PDZ domain protein 1.
UniProt Q4F893
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Ullmer, Schmuck, Figge et al.: "Cloning and characterization of MUPP1, a novel PDZ domain protein." in: FEBS letters, Vol. 424, Issue 1-2, pp. 63-8, 1998 (PubMed).

Lee, Glaunsinger, Mantovani et al.: "Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins." in: Journal of virology, Vol. 74, Issue 20, pp. 9680-93, 2000 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9...." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Hosts (18)
Reactivities (17), (13), (13), (12), (12)
Applications (10), (6), (4), (4), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (1), (1), (1), (1), (1)
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