Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) (AA 1050-1100) antibody

Details for Product No. ABIN350518
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Antigen
Synonyms NMDAR2A, nr2a, GRIN2A, EPND, GluN2A, NR2A
Epitope
AA 1050-1100
(40), (38), (20), (14), (14), (7), (7), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(89), (84), (48), (36), (27), (26), (25), (3), (1)
Host
Rabbit
(107), (41), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (8), (8), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(108), (71), (31), (30), (24), (20), (8), (8), (6), (3), (1)
Pubmed 5 references available
Quantity 500 μg
Options
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Availability Will be delivered in 7 to 8 Business Days
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Catalog No. ABIN350518
454.67 $
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Immunogen A synthetic peptide from aa region 1050-1100 of human NMDAR2A conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Isotype IgG
Specificity Specific for NMDAR2A.
Alternative Name NMDAR2A
Background Function: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane, Multi-pass membrane protein. Also known as: GRIN2A, Glutamate receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDE1, NR2A.
Research Area Neurology
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Foldes, Adams, Fantaske et al.: "Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein." in: Biochimica et biophysica acta, Vol. 1223, Issue 1, pp. 155-9, 1994 (PubMed).

Hess, Daggett, Crona et al.: "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors." in: The Journal of pharmacology and experimental therapeutics, Vol. 278, Issue 2, pp. 808-16, 1996 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Molina, Horn, Tang et al.: "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 7, pp. 2199-204, 2007 (PubMed).

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