Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2b (GRIN2B) (C-Term) antibody

Antigen: Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2b (GRIN2B)

Synonyms: GRIN2B, NMDAR2B, NR2B, Nmdar2b, AW490526, hNR3, MGC142178, MGC142180

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350519

Additional Information

Alternative name: NMDAR2B (GRIN2B) (c-terminal region)

Swiss-Prot: Q13224

Immunogen: A synthetic peptide from the c-terminal region of human NMDAR2B (GRIN2B) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse and rat.

Format: Lyophilized

Description: FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Also known as: GRIN2B, N-methyl-D-aspartate receptor subunit 3, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDE1, NR2B, NR3.

Specificity: Appears to be specific for NMDAR2B.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Mandich, Schito, Bellone et al.: "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12." in: Genomics, Vol. 22, Issue 1, pp. 216-8, 1994 (PubMed).

Adams, Foldes, Kamboj: "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein." in: Biochimica et biophysica acta, Vol. 1260, Issue 1, pp. 105-8, 1995 (PubMed).

Schito, Pizzuti, Di Maria et al.: "mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit." in: Neuroscience letters, Vol. 239, Issue 1, pp. 49-53, 1998 (PubMed).

Wu, Dowbenko, Spencer et al.: "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21477-85, 2000 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).