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GRIN2B antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (C-Term)

Details for Product anti-GRIN2B Antibody No. ABIN350519, Supplier: Log in to see
Antigen
  • NMDAR2B
  • GluN2B
  • MRD6
  • NR2B
  • hNR3
  • nmdar2b
  • nr2b
  • AW490526
  • Nmdar2b
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • GRIN2B
  • Grin2b
  • grin2b
Alternatives
anti-Rat (Rattus) GRIN2B antibody for Western Blotting
Epitope
C-Term
49
41
38
35
29
21
20
19
16
16
16
15
15
15
10
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
358
354
325
24
18
12
11
7
6
5
5
4
4
3
2
2
2
2
1
1
Host
Rabbit
320
61
16
Clonality
Polyclonal
Conjugate
This GRIN2B antibody is un-conjugated
12
12
10
9
9
9
9
9
9
9
9
9
8
8
5
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
260
115
93
80
77
66
58
37
30
11
4
3
3
2
1
1
Options
Supplier
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Immunogen A synthetic peptide from the c-terminal region of human NMDAR2B (GRIN2B) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in mouse and rat.
Specificity Specific for NMDAR2B.
Purification Whole serum
Alternative Name NMDAR2B (GRIN2B Antibody Abstract)
Background Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane, Multi-pass membrane protein. Also known as: GRIN2B, N-methyl-D-aspartate receptor subunit 3, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDE1, NR2B, NR3.
Research Area Neurology, Neurotransmitters, Receptors
Pathways Response to Growth Hormone Stimulus
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Munton, Tweedie-Cullen, Livingstone-Zatchej, Weinandy, Waidelich, Longo, Gehrig, Potthast, Rutishauser, Gerrits, Panse, Schlapbach, Mansuy: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Wu, Dowbenko, Spencer, Laura, Lee, Gu, Lasky: "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21477-85, 2000 (PubMed).

Schito, Pizzuti, Di Maria, Schenone, Ratti, Defferrari, Bellone, Mancardi, Ajmar, Mandich: "mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit." in: Neuroscience letters, Vol. 239, Issue 1, pp. 49-53, 1998 (PubMed).

Adams, Foldes, Kamboj: "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein." in: Biochimica et biophysica acta, Vol. 1260, Issue 1, pp. 105-8, 1995 (PubMed).

Mandich, Schito, Bellone, Antonacci, Finelli, Rocchi, Ajmar: "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12." in: Genomics, Vol. 22, Issue 1, pp. 216-8, 1994 (PubMed).