GRIN2B antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (C-Term)

Details for Product anti-GRIN2B Antibody No. ABIN350520, Supplier: Log in to see
Antigen
  • NMDAR2B
  • GluN2B
  • MRD6
  • NR2B
  • hNR3
  • nmdar2b
  • nr2b
  • AW490526
  • Nmdar2b
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • GRIN2B
  • Grin2b
  • grin2b
Alternatives
anti-Rat (Rattus) GRIN2B antibody for Western Blotting
Epitope
C-Term
68
50
47
39
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30
19
19
16
16
16
15
15
15
10
5
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3
3
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2
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2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
377
359
325
25
19
13
11
7
6
5
4
4
4
3
2
2
2
2
1
1
Host
Rabbit
317
91
15
Clonality
Polyclonal
Conjugate
This GRIN2B antibody is un-conjugated
14
14
12
11
11
9
9
9
9
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9
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8
5
3
3
2
2
2
2
2
2
2
2
2
2
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2
2
2
2
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2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
284
120
115
105
94
74
63
59
12
5
4
3
3
2
1
1
Options
Supplier
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Immunogen A synthetic peptide from the c-terminal region of human NMDAR2B (GRIN2B) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse and rat.
Isotype IgG
Specificity Specific for NMDAR2B.
Alternative Name NMDAR2B (GRIN2B Antibody Abstract)
Background Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane, Multi-pass membrane protein. Also known as: GRIN2B, N-methyl-D-aspartate receptor subunit 3, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDE1, NR2B, NR3.
Research Area Neurology, Neurotransmitters, Receptors
Pathways Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Munton, Tweedie-Cullen, Livingstone-Zatchej, Weinandy, Waidelich, Longo, Gehrig, Potthast, Rutishauser, Gerrits, Panse, Schlapbach, Mansuy: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Wu, Dowbenko, Spencer, Laura, Lee, Gu, Lasky: "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21477-85, 2000 (PubMed).

Schito, Pizzuti, Di Maria, Schenone, Ratti, Defferrari, Bellone, Mancardi, Ajmar, Mandich: "mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit." in: Neuroscience letters, Vol. 239, Issue 1, pp. 49-53, 1998 (PubMed).

Adams, Foldes, Kamboj: "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein." in: Biochimica et biophysica acta, Vol. 1260, Issue 1, pp. 105-8, 1995 (PubMed).

Mandich, Schito, Bellone, Antonacci, Finelli, Rocchi, Ajmar: "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12." in: Genomics, Vol. 22, Issue 1, pp. 216-8, 1994 (PubMed).

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