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Nogo (RTN4, Neurite outgrowth inhibitor, Reticulon-4) (Internal Region) antibody
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from internal region of human Nogo (RTN4, Neurite outgrowth inhibitor, Reticulon-4) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||Function: Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Anchored to the membrane of the endoplasmic reticulum through 2 putativetransmembrane domains. Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific. Also known as: RTN4, Neurite outgrowth inhibitor, Reticulon-4, Nogo protein, Foocen, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5.|
|Specificity||Appears to be specific for Nogo.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Purification||The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Prinjha, Moore, Vinson et al.: "Inhibitor of neurite outgrowth in humans." in: Nature, Vol. 403, Issue 6768, pp. 383-4, 2000 (PubMed).
Yang, Yu, Bi et al.: "Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 88, Issue 1-2, pp. 101-2, 2000 (PubMed).
Tagami, Eguchi, Kinoshita et al.: "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity." in: Oncogene, Vol. 19, Issue 50, pp. 5736-46, 2000 (PubMed).
Zhou, Sha, Li et al.: "Expression of a novel reticulon-like gene in human testis." in: Reproduction (Cambridge, England), Vol. 123, Issue 2, pp. 227-34, 2002 (PubMed).
Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).
|Hosts||Goat (1), Rabbit (1)|
|Applications||Immunohistochemistry (IHC) (2), Western Blotting (WB) (2)|
|Epitopes||Internal Region (2)|