Reticulon 4 (RTN4) (AA 460-510) antibody

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Antigen
  • RTN4-Cw
  • DKFZp459C0314
  • NOGO
  • NOGO-A
  • reticulon-4
  • ASY
  • NI220/250
  • NOGOC
  • NSP
  • NSP-CL
  • Nbla00271
  • Nbla10545
  • Nogo-B
  • Nogo-C
  • RTN-X
  • RTN4-A
  • RTN4-B1
  • RTN4-B2
  • RTN4-C
  • 1110020G17Rik
  • AA407876
  • AA409940
  • AA960376
  • C130026I10Rik
  • NgA
  • Nogo-A
  • mKIAA0886
  • mKIAA4153
  • NI-250
  • Nogo
  • Vp20
  • r
  • rat N
  • rat NogoA
  • NGR
  • NOGOR
  • NgR
  • NgR1
  • Nogor
  • reticulon 4
  • reticulon 4 receptor
  • RTN4
  • rtn4
  • Rtn4
  • RTN4R
  • Rtn4r
Alternatives
anti-Human Reticulon 4 antibody for Simple Western
Epitope
AA 460-510
16
16
15
12
11
5
5
5
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
129
109
109
10
8
8
8
8
5
5
4
3
1
1
1
Host
Rabbit
134
11
5
3
2
Clonality
Polyclonal
Conjugate
Un-conjugated
6
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
115
55
49
45
26
11
9
9
4
2
2
Options
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Immunogen A synthetic peptide from aa region 460-510 of human NOGO conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for Nogo.
Purification Whole serum
Alternative Name NOGO (RTN4 Antibody Abstract)
Background Function: Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS.
Subcellular location: Endoplasmic reticulum membrane, Multi-pass membrane protein. Note: Anchored to the membrane of the endoplasmic reticulum through 2 putativetransmembrane domains.
Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific. Also known as: RTN4, Neurite outgrowth inhibitor, Reticulon-4, Nogo protein, Foocen, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5.
Pathways Neurotrophin Signaling Pathway, Regulation of Cell Size
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Zhou, Sha, Li, Lin, Zhu, Zhou, Wang, Zhu, Wang, Zhou: "Expression of a novel reticulon-like gene in human testis." in: Reproduction (Cambridge, England), Vol. 123, Issue 2, pp. 227-34, 2002 (PubMed).

Prinjha, Moore, Vinson, Blake, Morrow, Christie, Michalovich, Simmons, Walsh: "Inhibitor of neurite outgrowth in humans." in: Nature, Vol. 403, Issue 6768, pp. 383-4, 2000 (PubMed).

Tagami, Eguchi, Kinoshita, Takeda, Tsujimoto: "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity." in: Oncogene, Vol. 19, Issue 50, pp. 5736-46, 2000 (PubMed).

Yang, Yu, Bi, Zhao: "Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 88, Issue 1-2, pp. 101-2, 2000 (PubMed).