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Details for Product No. ABIN350521

Reticulon 4 (RTN4) (Internal Region) antibody

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ASY, NSP, NOGO, NOGOC, RTN-X, NOGO-A, NSP-CL, Nogo-B, Nogo-C, RTN4-A, RTN4-C, RTN4-B1, RTN4-B2, NI220/250, Nbla00271, Nbla10545, 1110020G17Rik, AA407876, AA409940, AA960376, C130026I10Rik, NgA, Nogo-A ... show more
»Alternatives Internal Region
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350521
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from internal region of human Nogo (RTN4, Neurite outgrowth inhibitor, Reticulon-4) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for Nogo.
Purification The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Purity whole serum
Alternative Name Nogo (RTN4, Neurite outgrowth inhibitor, Reticulon-4)
Background Function: Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS.
Subcellular location: Endoplasmic reticulum membrane, Multi-pass membrane protein. Note: Anchored to the membrane of the endoplasmic reticulum through 2 putativetransmembrane domains.
Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific. Also known as: RTN4, Neurite outgrowth inhibitor, Reticulon-4, Nogo protein, Foocen, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5.
UniProt Q9NQC3
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Prinjha, Moore, Vinson et al.: "Inhibitor of neurite outgrowth in humans." in: Nature, Vol. 403, Issue 6768, pp. 383-4, 2000 (PubMed).

Yang, Yu, Bi et al.: "Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 88, Issue 1-2, pp. 101-2, 2000 (PubMed).

Tagami, Eguchi, Kinoshita et al.: "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity." in: Oncogene, Vol. 19, Issue 50, pp. 5736-46, 2000 (PubMed).

Zhou, Sha, Li et al.: "Expression of a novel reticulon-like gene in human testis." in: Reproduction (Cambridge, England), Vol. 123, Issue 2, pp. 227-34, 2002 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Alternatives for antigen "Reticulon 4 (RTN4)", type "Antibodies"
Hosts (80), (5), (3), (3), (1)
Reactivities (79), (61), (57), (3), (2), (2), (1)
Applications (77), (48), (31), (26), (10), (6), (5), (2), (2)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (14), (7), (6), (6), (3), (1), (1), (1), (1), (1), (1), (1)