Reticulon 4 (RTN4) (Internal Region) antibody

Details for Product No. ABIN350521
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Antigen
Synonyms
ASY, NSP, NOGO, NOGOC, RTN-X, NOGO-A, NSP-CL, Nogo-B, Nogo-C, RTN4-A, RTN4-C, RTN4-B1, RTN4-B2, NI220/250, Nbla00271, Nbla10545, 1110020G17Rik, AA407876, AA409940, AA960376, C130026I10Rik, NgA, Nogo-A ... show more
ASY, NSP, NOGO, NOGOC, RTN-X, NOGO-A, NSP-CL, Nogo-B, Nogo-C, RTN4-A, RTN4-C, RTN4-B1, RTN4-B2, NI220/250, Nbla00271, Nbla10545, 1110020G17Rik, AA407876, AA409940, AA960376, C130026I10Rik, NgA, Nogo-A, mKIAA0886, mKIAA4153, NI-250, Nogo, Vp20, r, rat N, rat NogoA, reticulon-4, RTN4-Cw, DKFZp459C0314 show less
Epitope
Internal Region
(17), (15), (12), (6), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(90), (73), (73), (3), (2), (2), (1)
Host
Rabbit
(102), (6), (4), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(91), (59), (33), (32), (20), (7), (6), (2), (2)
Pubmed 5 references available
Catalog no. ABIN350521
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from internal region of human Nogo (RTN4, Neurite outgrowth inhibitor, Reticulon-4) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for V1RA3 and V1RA4.
Purification The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
whole serum
Alternative Name Nogo (RTN4, Neurite outgrowth inhibitor, Reticulon-4)
Background Function: Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS.
Subcellular location: Endoplasmic reticulum membrane, Multi-pass membrane protein. Note: Anchored to the membrane of the endoplasmic reticulum through 2 putativetransmembrane domains.
Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific. Also known as: RTN4, Neurite outgrowth inhibitor, Reticulon-4, Nogo protein, Foocen, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5.
UniProt Q9EQ51
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Prinjha, Moore, Vinson et al.: "Inhibitor of neurite outgrowth in humans." in: Nature, Vol. 403, Issue 6768, pp. 383-4, 2000 (PubMed).

Yang, Yu, Bi et al.: "Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 88, Issue 1-2, pp. 101-2, 2000 (PubMed).

Tagami, Eguchi, Kinoshita et al.: "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity." in: Oncogene, Vol. 19, Issue 50, pp. 5736-46, 2000 (PubMed).

Zhou, Sha, Li et al.: "Expression of a novel reticulon-like gene in human testis." in: Reproduction (Cambridge, England), Vol. 123, Issue 2, pp. 227-34, 2002 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Hosts (102), (6), (4), (3), (2)
Reactivities (90), (73), (73), (3), (2), (2), (1)
Applications (91), (59), (33), (32), (20), (7), (6), (2), (2)
Conjugates (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (17), (15), (12), (6), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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