Olfactory Receptor, Family 1, Subfamily F, Member 12 (OR1F12) antibody

Antigen: Olfactory Receptor, Family 1, Subfamily F, Member 12 (OR1F12)

Synonyms: OR6-12, OR1F12P, OR1F12Q, hs6M1-35P

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350619

Additional Information

Alternative name: olfactory receptor (OR1F12, OR6-12)

UniProt: Q8NHA8

Immunogen: A synthetic peptide as a part of human olfactory receptor (OR1F12, OR6-12) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. Theolfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. Theolfactory receptor gene family is the largest in the genome. FUNCTION: Odorant receptor SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Useful Links <||a href="http://bioportal.weizmann.ac.il/HORDE/links.html" > The Humanolfactory Data Exploratorium: HORDE <||/a> <||a href="http://senselab.med.yale.edu/senselab/ordb/" >olfactory Receptor Data Base: ORDB <||/a> Also known as: OR1FC,olfactory receptor 1F12, OR1F12, OR6-12 Hs6M1-35P, OR1F12P.

Specificity: Appears to be specific for Olfactory receptor OR1F12.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 200 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Rouquier, Taviaux, Trask et al.: "Distribution of olfactory receptor genes in the human genome." in: Nature genetics, Vol. 18, Issue 3, pp. 243-50, 1998 (PubMed).

Glusman, Sosinsky, Ben-Asher et al.: "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster." in: Genomics, Vol. 63, Issue 2, pp. 227-45, 2000 (PubMed).

Fuchs, Malecova, Linhart et al.: "DEFOG: a practical scheme for deciphering families of genes." in: Genomics, Vol. 80, Issue 3, pp. 295-302, 2002 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).