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Details for Product No. ABIN350656

Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) (N-Term) antibody

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Antigen
Synonyms BHLHB1, OLIGO2, RACK17, PRKCBP2, bHLHe19, AI604895, Bhlhb1, Olg-2, Oligo2, RK17, wu:fc64g09, olig3.2, MGC89336, OLIG2
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350656
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal region of human OLIG2 (Oligo2, bHLHB1, RACK17) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Specificity Appears to be specific for OLIG2.
Purification Purified mouse LN T cells
Purity whole serum
Alternative Name OLIG2 (Oligo2, bHLHB1, RACK17)
Background Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
Subcellular location: Nucleus. Cytoplasm
Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. Involvement in disease: A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14,21)(q11.2,q22) with TCRA. Also known as: Basic helix loop helix protein class B 1, BHLHB1, olig2, OLIGO2, Oligodendrocyte specific bHLH transcription factor 2, Oligodendrocyte transcription factor 2, PRKCBP2, Protein kinase C binding protein 2, Protein kinase C binding protein RACK17, RACK17.
UniProt Q13516
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Wang, Jani-Sait, Escalon et al.: "The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3497-502, 2000 (PubMed).

Marie, Sanson, Mokhtari et al.: "OLIG2 as a specific marker of oligodendroglial tumour cells." in: Lancet, Vol. 358, Issue 9278, pp. 298-300, 2001 (PubMed).

Lu, Park, Noll et al.: "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 19, pp. 10851-6, 2001 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Alternatives for antigen "Oligodendrocyte Lineage Transcription Factor 2 (OLIG2)", type "Antibodies"
Hosts (64), (12), (4), (2)
Reactivities (72), (39), (35), (14), (13), (12), (12), (1), (1)
Applications (69), (34), (30), (15), (12), (10), (8), (7), (7), (3), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (8), (6), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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