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Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) (N-Term) antibody
|Synonyms||BHLHB1, OLIGO2, RACK17, PRKCBP2, bHLHe19, wu:fc64g09, OLIG2, olig3.2, MGC89336|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|4 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||OLIG2 (Oligo2, bHLHB1, RACK17)|
|Immunogen||A synthetic peptide from the n-terminal region of human OLIG2 (Oligo2, bHLHB1, RACK17) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.|
|Description||Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. Subcellular location: Nucleus. Cytoplasm Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. Involvement in disease: A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. Also known as: Basic helix loop helix protein class B 1, BHLHB1, olig2, OLIGO2, Oligodendrocyte specific bHLH transcription factor 2, Oligodendrocyte transcription factor 2, PRKCBP2, Protein kinase C binding protein 2, Protein kinase C binding protein RACK17, RACK17.|
|Specificity||Appears to be specific for OLIG2.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Purification||Purified mouse LN T cells|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Wang, Jani-Sait, Escalon et al.: "The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3497-502, 2000 (PubMed).
Marie, Sanson, Mokhtari et al.: "OLIG2 as a specific marker of oligodendroglial tumour cells." in: Lancet, Vol. 358, Issue 9278, pp. 298-300, 2001 (PubMed).
Lu, Park, Noll et al.: "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 19, pp. 10851-6, 2001 (PubMed).
Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).
|Hosts||Rabbit (51), Mouse (5), Sheep (3), Goat (1)|
|Reactivities||Human (53), Mouse (Murine) (34), Rat (Rattus) (31), Chicken (21), Cow (Bovine) (3), Cat (Feline) (1), Dog (Canine) (1)|
|Applications||Western Blotting (WB) (42), Immunohistochemistry (IHC) (26), Immunofluorescence (IF) (21), ELISA (20), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (11), Immunoprecipitation (IP) (6), Immunocytochemistry (ICC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)|
|Epitopes||N-Term (6), C-Term (3), AA 70-120 (1), Internal Region (1), pSer147 (1)|