Opsin 1 (Cone Pigments), Short-Wave-Sensitive (OPN1SW) (internal) antibody

Antigen: Opsin 1 (Cone Pigments), Short-Wave-Sensitive (OPN1SW)

Synonyms: BCP, BOP, CBT, Bcp, AW551857, SWS2, bluops, zfblue, SI:zK13A21.5 (blue-sensitive opsin), OPN1SW, Blop, GB13493, SWS1, bcp, bop, cbt

Epitope: internal

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350676

Additional Information

Alternative name: OPSB (blue sensitive opsin, S opsin) (internal region)

Swiss-Prot: P03999

Immunogen: A synthetic peptide from the internal region of human OPSB (blue sensitive opsin, S opsin, BOP, OPN1SW, BCP, CBT) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in many species including mouse, rat, guinea pig and chicken.

Format: Lyophilized

Description: FUNCTION: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expresssed in cone photoreceptor cells. Also known as: Blue-sensitive opsin, BOP, blue cone photoreceptor pigment, OPN1SW, BCP, CBT, short wavelength-sensitive cone opsin, S opsin.

Specificity: Appears to be specific for OPSB.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Oprian, Asenjo, Lee et al.: "Design, chemical synthesis, and expression of genes for the three human color vision pigments." in: Biochemistry, Vol. 30, Issue 48, pp. 11367-72, 1992 (PubMed).

Zhao, Haeseleer, Fariss et al.: "Molecular cloning and localization of rhodopsin kinase in the mammalian pineal." in: Visual neuroscience, Vol. 14, Issue 2, pp. 225-32, 1997 (PubMed).

Gunther, Neitz, Neitz: "A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect." in: Visual neuroscience, Vol. 23, Issue 3-4, pp. 403-9, 2006 (PubMed).