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Rhodopsin antibody (RHO) (4th Cytoplasmic Loop)

Details for Product anti-RHO Antibody No. ABIN350678, Supplier: Login to see
Antigen
  • CG5279
  • DMELRH5
  • Dm Rh5
  • Dmel\\CG5279
  • RH5
  • Rh
  • rh5
  • CG9668
  • DMELRH4
  • Dm Rh4
  • Dmel\\CG9668
  • FBgn0003250
  • RH4
  • rh4
  • CG5192
  • DMELRH6
  • Dm Rh6
  • Dmel\\CG5192
  • R8
  • RH6
  • rh6
  • 143283_at
  • 1F9
  • BEST:GH11778
  • CG4550
  • DMELRH1
  • DRh1
  • Dm Rh1
  • DmRh1
  • Dmel\\CG4550
  • FBgn0002940
  • Nina E
  • NinaE
  • R
  • RH1
  • Rh-1
  • Rh1
  • Rh1(ninaE)
  • Rh1/ninaE
  • opsin
  • ora
  • rh1
  • rh1/ninaE
  • rhodopsin
  • CG10888
  • DMELRH3
  • Dm Rh3
  • Dmel\\CG10888
  • FBgn0003249
  • RH3
  • rh3
  • opn2
  • rp4
  • xrho
  • RHO
  • kfh-rh
  • RDP1
  • CSNBAD1
  • OPN2
  • RP4
  • Noerg1
  • Opn2
  • Ops
  • fi06d11
  • wu:fi06d11
  • zfo2
  • zfrho
  • PIGRHO1
  • ops
Epitope
4th Cytoplasmic Loop
13
8
4
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Chemical
83
39
24
14
5
3
2
1
1
1
Host
Rabbit
116
34
3
1
Clonality
Polyclonal
Conjugate
This Rhodopsin antibody is un-conjugated
8
6
6
6
6
4
4
4
4
4
4
4
4
4
4
4
4
Application
Immunohistochemistry (IHC), Western Blotting (WB)
143
111
90
80
76
70
20
4
4
1
Supplier
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Immunogen A synthetic peptide from the 4th cytoplasmic loop of human OPSD (rhodopsin, opsin-2, RHO, OPN2, RP4) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for OPSD.
Purification Whole serum
Alternative Name Rhodopsin (RHO Antibody Abstract)
Target Type Chemical
Background Function: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. BIOPHYSICOCHEMICAL PROPERTIES: Absorption: Abs(max)=495 nm,
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Rod shaped photoreceptor cells which mediates vision in dim light. PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. DISEASE: Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant. DISEASE: Defects in RHO are a cause of retinitis pigmentosa autosomal recessive (ARRP). DISEASE: Defects in RHO are a cause of autosomal dominant congenital stationary night blindness 1 (CSNBAD1), also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a nonprogressive retinal disorder characterized by impaired night vision and ocular symptoms such as myopia, hyperopia, nystagmus and reduced visual acuity. Also known as: Rhodopsin, opsin-2, RHO, OPN2, RP4, MGC138309, MGC138311.
Research Area Neurology
Pathways WNT Signaling
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Lee, Shin, Cho et al.: "Detection of vivax malaria sporozoites naturally infected in Anopheline mosquitoes from endemic areas of northern parts of Gyeonggi-do (Province) in Korea." in: The Korean journal of parasitology, Vol. 40, Issue 2, pp. 75-81, 2002 (PubMed).

Bennett, Sun, Karikuo: "Sequence analysis of the 5.34-kb 5' flanking region of the human rhodopsin-encoding gene." in: Gene, Vol. 167, Issue 1-2, pp. 317-20, 1996 (PubMed).

Macke, Davenport, Jacobson et al.: "Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsin." in: American journal of human genetics, Vol. 53, Issue 1, pp. 80-9, 1993 (PubMed).

Vaithinathan, Berson, Dryja: "Further screening of the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa." in: Genomics, Vol. 21, Issue 2, pp. 461-3, 1994 (PubMed).

Sieving, Richards, Naarendorp et al.: "Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 3, pp. 880-4, 1995 (PubMed).

Macke, Hennessey, Nathans: "Rhodopsin mutation proline347-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347." in: Human molecular genetics, Vol. 4, Issue 4, pp. 775-6, 1995 (PubMed).

Nathans, Hogness: "Isolation and nucleotide sequence of the gene encoding human rhodopsin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 15, pp. 4851-5, 1984 (PubMed).

Dryja, McGee, Reichel et al.: "A point mutation of the rhodopsin gene in one form of retinitis pigmentosa." in: Nature, Vol. 343, Issue 6256, pp. 364-6, 1990 (PubMed).

Sung, Davenport, Hennessey et al.: "Rhodopsin mutations in autosomal dominant retinitis pigmentosa." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 15, pp. 6481-5, 1991 (PubMed).

Farrar, Findlay, Kumar-Singh et al.: "Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked family." in: Human molecular genetics, Vol. 1, Issue 9, pp. 769-71, 1993 (PubMed).