Greenred-Sensitive Opsin 1 (OPSG/OPSR) antibody

Antigen: Greenred-Sensitive Opsin 1 (OPSG/OPSR)

Synonyms: RH2-2, grops1, grops2, wu:fk57c11, si:zc263a23.4, RH2-3, si:zc263a23.3

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350679

Additional Information

Alternative name: OPSG and OPSR (greenred-sensitive opsin opsin 1, M opsin)

UniProt: P04001

Immunogen: A synthetic peptide from human OPSG and OPSR (green & red-sensitive opsin, OPN1MW, OPN1LW, GCP, RCP, CBBM, opsin 1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. BIOPHYSICOCHEMICAL PROPERTIES: Absorption:       Abs(max)=530 nm; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: The three color pigments are found in the cone photoreceptor cells. PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. DISEASE: Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD); also called deuteranopia. Also known as: Green-sensitive opsin, green cone photoreceptor pigment, OPN1MW, OPN1LW, GCP, RCP, CBBM, OPN1MW1, opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan), red-sensitive opsin, red cone photoreceptor pigment, M opsin.

Specificity: Appears to be specific for OPSG and OPSR.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Winderickx, Sanocki, Lindsey et al.: "Defective colour vision associated with a missense mutation in the human green visual pigment gene." in: Nature genetics, Vol. 1, Issue 4, pp. 251-6, 1993 (PubMed).

Nathans, Thomas, Hogness: "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments." in: Science (New York, N.Y.), Vol. 232, Issue 4747, pp. 193-202, 1986 (PubMed).

Applebury, Hargrave: "Molecular biology of the visual pigments." in: Vision research, Vol. 26, Issue 12, pp. 1881-95, 1987 (PubMed).