Opsin 4 (OPN4) (AA 2-70) antibody

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Synonyms Gm533, 1110007J02Rik, MOP, opn4, opn4l, opn4m2, OPN4-2, cOpn4L, melanopsin, opn4-A, Xmop, opn4d
AA 2-70
(6), (1), (1), (1), (1), (1), (1), (1), (1)
(15), (5), (4)
(18), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(18), (12), (4), (3), (2), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN350682
Quantity 100 µL
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Immunogen A synthetic peptide from AA 2-70 of mouse melanopsin conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for Olfactory receptor OR4C11.
Purification whole serum
Alternative Name opsin-4 (OPN4, melanopsin, MOP, Mopn)
Background Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.
Function: Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal.
Subcellular location: Membrane, Multi-pass membrane protein. Note: Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells .
Tissue specificity: Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina. Also known as: Similar to melanopsin, opsin-4, OPN4, melanopsin, MOP, Mopn, LOC721663.
UniProt Q6IEV9
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Provencio, Rodriguez, Jiang et al.: "A novel human opsin in the inner retina." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 2, pp. 600-5, 2000 (PubMed).

Hattar, Lucas, Mrosovsky et al.: "Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice." in: Nature, Vol. 424, Issue 6944, pp. 76-81, 2003 (PubMed).

Hosts (18), (1)
Reactivities (15), (5), (4)
Applications (18), (12), (4), (3), (2), (2), (2), (1)
Epitopes (6), (1), (1), (1), (1), (1), (1), (1), (1)
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