Opsin 5 (OPN5) antibody

Antigen: Opsin 5 (OPN5)

Synonyms: PGR12, TMEM13, NEUROPSIN, Gpr136, Neuropsin, cOpn5L2, neuropsin

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350683

Additional Information

Alternative name: opsin-5 (OPN5, opsin 5, neuropsin, GPR136, PGR12, TMEM13)

UniProt: Q6U736

Immunogen: A synthetic peptide as a part of human opsin-5 (OPN5, opsin 5, neuropsin, GPR136, PGR12, TMEM13) conjugated to immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this gene may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants encoding different isoforms. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Detected in brain and retina and cell lines derived from neural retina. Also known as: Neuropsin, G-protein coupled receptor 136, G-protein coupled receptor PGR12,transmembrane protein 13, GPR136, PGR12, TMEM13.

Specificity: Appears to be specific for opsin-5.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Vassilatis, Hohmann, Zeng et al.: "The G protein-coupled receptor repertoires of human and mouse." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 8, pp. 4903-8, 2003 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Fredriksson, Hoeglund, Gloriam et al.: "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives." in: FEBS letters, Vol. 554, Issue 3, pp. 381-8, 2003 (PubMed).

Tarttelin, Bellingham, Hankins et al.: "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue." in: FEBS letters, Vol. 554, Issue 3, pp. 410-6, 2003 (PubMed).