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Opsin 5 (OPN5) antibody
|Synonyms||PGR12, TMEM13, NEUROPSIN, Gpr136, Neuropsin, cOpn5L2, neuropsin|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||Opsin-5 (GPR136, TMEM13)|
|Immunogen||A synthetic peptide as a part of mouse, rat and human opsin-5 (OPN5, opsin 5, neuropsin, GPR136, PGR12, TMEM13) conjugated to immunogenic carrier protein was used as the immunogen.|
|Description||Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this gene may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants encoding different isoforms. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Detected in the eye, testis, brain, retina and cell lines derived from neural retina. Also known as: Opsin-5, neuropsin, G-protein coupled receptor 136, G-protein coupled receptor PGR12, OPN5, opsin 5, GPR136, TMEM13.|
|Specificity||Appears to be specific for opsin-5.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Vassilatis, Hohmann, Zeng et al.: "The G protein-coupled receptor repertoires of human and mouse." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 8, pp. 4903-8, 2003 (PubMed).
Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).
Fredriksson, Hoeglund, Gloriam et al.: "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives." in: FEBS letters, Vol. 554, Issue 3, pp. 381-8, 2003 (PubMed).
Tarttelin, Bellingham, Hankins et al.: "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue." in: FEBS letters, Vol. 554, Issue 3, pp. 410-6, 2003 (PubMed).
Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).
|Reactivities||Human (12), Mouse (Murine) (1)|
|Applications||Western Blotting (WB) (9), ELISA (3), Immunofluorescence (IF) (3), Immunohistochemistry (Paraffin-embedded Sections) pro (IHC (p)+) (2), Immunohistochemistry (IHC) (1), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1)|
|Epitopes||C-Term (4), Cleaved-Val33 (1), Transmembrane Domain (1)|