ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2) (C-Term) antibody

Antigen: ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2)

Synonyms: CBCIP2, C7orf19, MEM142B, FLJ12474, FLJ14733, FLJ44818, TMEM142B, Tmem142b, A730041O15Rik, RGD1310213, ORAI2, orai1, orai-1, tmem142a, MGC115378, Orai2, LOC100230993

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350686

Additional Information

Alternative name: Orai2 (TMEM142b)

UniProt: Q8BH10

Immunogen: A synthetic peptide from the c-terminal region of mouse Orai2 (TMEM142b) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and human.

Format: Lyophilized

Description: FUNCTION: Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Protein orai-2,transmembrane protein 142B, CAP-binding protein complex-interacting protein 2, C7orf19, CBCIP2, TMEM142B.

Specificity: Appears to be specific for Orai2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Hillier, Fulton, Fulton et al.: "The DNA sequence of human chromosome 7." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Feske, Gwack, Prakriya et al.: "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function." in: Nature, Vol. 441, Issue 7090, pp. 179-85, 2006 (PubMed).

Mercer, Dehaven, Smyth et al.: "Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1." in: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24979-90, 2006 (PubMed).