Hypocretin (Orexin) Receptor 1 (HCRTR1) (Internal Region) antibody

Details for Product No. ABIN350687
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Antigen
Synonyms OX1R, Hctr1, Ox1r, LOC443167, HCRTR1
Epitope
Internal Region
(8), (7), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Human
(51), (24), (21), (1), (1), (1)
Host
Rabbit
(46), (5), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(31), (25), (16), (5), (2), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN350687
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the internal region of mouse Orexin Receptor 1 (OX1R) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat.
Specificity Specific for SEC10.
Purification whole serum
Alternative Name Orexin Receptor 1 (OX1R)
Background Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Orexin receptor type 1, OX1R, Hypocretin receptor type 1.
UniProt P97878
Research Area Signaling
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Sakurai, Amemiya, Ishii et al.: "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." in: Cell, Vol. 92, Issue 4, pp. 573-85, 1998 (PubMed).

Willie, Chemelli, Sinton et al.: "To eat or to sleep? Orexin in the regulation of feeding and wakefulness." in: Annual review of neuroscience, Vol. 24, pp. 429-58, 2001 (PubMed).

Hungs, Mignot: "Hypocretin/orexin, sleep and narcolepsy." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 23, Issue 5, pp. 397-408, 2001 (PubMed).

Hosts (46), (5), (1)
Reactivities (51), (24), (21), (1), (1), (1)
Applications (31), (25), (16), (5), (2), (1), (1), (1)
Epitopes (8), (7), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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