Hypocretin (Orexin) Receptor 1 (HCRTR1) (Internal Region) antibody
| Antigen |
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| Synonyms |
OX1R, LOC443167, HCRTR1, Hctr1, Ox1r, MGC141357 |
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Binding Site
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| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
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| Catalog no. |
ABIN350687 |
| Quantity |
100 µl |
| Price |
454.67 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 7 to 8 Business Days |
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Alternative name
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Orexin Receptor 1 (OX1R)
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UniProt
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P58307
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Immunogen
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A synthetic peptide from the internal region of mouse Orexin Receptor 1 (OX1R) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat.
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Format
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Lyophilized
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Description
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FUNCTION: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade. Subcellular location: Cell membrane; Multi-pass membrane protein. Also known as: Orexin receptor type 1, OX1R, Hypocretin receptor type 1.
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Specificity
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Appears to be specific for Orexin Receptor 1.
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Application Notes
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IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
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Purity
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whole serum
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Storage
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Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
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Restrictions
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For Research Use only
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Sakurai, Amemiya, Ishii et al.: "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." in: Cell, Vol. 92, Issue 4, pp. 573-85, 1998 (PubMed).
Willie, Chemelli, Sinton et al.: "To eat or to sleep? Orexin in the regulation of feeding and wakefulness." in: Annual review of neuroscience, Vol. 24, pp. 429-58, 2001 (PubMed).
Hungs, Mignot: "Hypocretin/orexin, sleep and narcolepsy." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 23, Issue 5, pp. 397-408, 2001 (PubMed).
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Alternatives for antigen "Hypocretin (Orexin) Receptor 1 (HCRTR1)", type "Antibodies"
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Hosts
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Rabbit (29), Goat (4), Chicken (2)
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Reactivities
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Human (33), Rat (Rattus) (11), Mouse (Murine) (7), Dog (Canine) (1), Pig (Porcine) (1), Sheep (Ovine) (1)
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Applications
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Western Blotting (WB) (23), ELISA (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Immunohistochemistry (IHC) (3), Immunofluorescence (IF) (2), Immunoprecipitation (IP) (2), Dot Blot (DB) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1)
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Epitopes
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Internal Region (7), C-Term (6), N-Term (6), AA 327-342 (1), Center (1), Cytoplasmic Domain (1), Extracellular Domain (1), Internal Region,AA 269-298 (1)
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