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Details for Product No. ABIN350687

Hypocretin (Orexin) Receptor 1 (HCRTR1) (Internal Region) antibody

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Antigen
Synonyms OX1R, Hctr1, Ox1r, LOC443167, HCRTR1
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350687
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of mouse Orexin Receptor 1 (OX1R) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat.
Specificity Appears to be specific for Orexin Receptor 1.
Purity whole serum
Alternative Name Orexin Receptor 1 (OX1R)
Background Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Orexin receptor type 1, OX1R, Hypocretin receptor type 1.
UniProt P58307
Application Notes IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Sakurai, Amemiya, Ishii et al.: "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." in: Cell, Vol. 92, Issue 4, pp. 573-85, 1998 (PubMed).

Willie, Chemelli, Sinton et al.: "To eat or to sleep? Orexin in the regulation of feeding and wakefulness." in: Annual review of neuroscience, Vol. 24, pp. 429-58, 2001 (PubMed).

Hungs, Mignot: "Hypocretin/orexin, sleep and narcolepsy." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 23, Issue 5, pp. 397-408, 2001 (PubMed).

Alternatives for antigen "Hypocretin (Orexin) Receptor 1 (HCRTR1)", type "Antibodies"
Hosts (46), (5), (2)
Reactivities (52), (22), (18), (1), (1), (1), (1)
Applications (30), (23), (17), (5), (2), (2), (1), (1), (1)
Epitopes (9), (7), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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