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Details for Product No. ABIN350688

Hypocretin (Orexin) Receptor 1 (HCRTR1) (N-Term) antibody

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Antigen
Synonyms OX1R, Hctr1, Ox1r, LOC443167, HCRTR1
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350688
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal region of human Orexin Receptor 1 (OX1R) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for Orexin Receptor 1.
Purity whole serum
Alternative Name Orexin Receptor 1 (OX1R)
Background Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Orexin receptor type 1, OX1R, Hypocretin receptor type 1.
UniProt O43613
Application Notes IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Sakurai, Amemiya, Ishii et al.: "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." in: Cell, Vol. 92, Issue 4, pp. 573-85, 1998 (PubMed).

Peyron, Faraco, Rogers et al.: "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains." in: Nature medicine, Vol. 6, Issue 9, pp. 991-7, 2000 (PubMed).

Olafsduottir, Rye, Scammell et al.: "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy." in: Neurology, Vol. 57, Issue 10, pp. 1896-9, 2001 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Alternatives for antigen "Hypocretin (Orexin) Receptor 1 (HCRTR1)", type "Antibodies"
Hosts (46), (5), (2)
Reactivities (51), (23), (19), (1), (1), (1), (1)
Applications (30), (23), (17), (5), (2), (2), (1), (1), (1)
Epitopes (10), (7), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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