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Hypocretin (Orexin) Receptor 1 (HCRTR1) (N-Term) antibody

Details for Product No. ABIN350688
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Antigen
Synonyms OX1R, Hctr1, Ox1r, LOC443167, HCRTR1
Epitope
N-Term
(15), (8), (7), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(58), (24), (20), (1), (1), (1), (1)
Host
Rabbit
(54), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(38), (31), (16), (5), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 100 µL
Options
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Catalog No. ABIN350688
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the n-terminal region of human Orexin Receptor 1 (OX1R) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for CNGA1.
Purification whole serum
Alternative Name Orexin Receptor 1 (OX1R)
Background Function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Orexin receptor type 1, OX1R, Hypocretin receptor type 1.
UniProt P29974
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Sakurai, Amemiya, Ishii et al.: "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." in: Cell, Vol. 92, Issue 4, pp. 573-85, 1998 (PubMed).

Peyron, Faraco, Rogers et al.: "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains." in: Nature medicine, Vol. 6, Issue 9, pp. 991-7, 2000 (PubMed).

Olafsduottir, Rye, Scammell et al.: "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy." in: Neurology, Vol. 57, Issue 10, pp. 1896-9, 2001 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350688
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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