p2x2 (P2RX2) (cytoplasmic domain) antibody

Antigen: p2x2 (P2RX2)

Synonyms: P2x2, P2X2a, MGC129148, MGC129149

Epitope: cytoplasmic domain

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350692

Additional Information

Alternative name: P2X2 (P2RX2) (cytoplasmic domain)

Swiss-Prot: Q8K3P1

Immunogen: A synthetic peptide from the cytoplasmic domain of mouse P2X2 (P2RX2, P2X purinoceptor 2, Purinergic receptor, ATP receptor) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in human, guinea pig and rat.

Format: Lyophilized

Description: FUNCTION: Binding of this ligand gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: High levels in pituitary and vas deferens. Lower extent in spinal cord, bladder, brain, adrenal, testis, sensory epithelia from the inner ear. Also known as: P2RX2, P2X purinoceptor 2, Purinergic receptor, ATP receptor.

Specificity: Appears to be specific for P2RX2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Brake, Wagenbach, Julius: "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor." in: Nature, Vol. 371, Issue 6497, pp. 519-23, 1994 (PubMed).

Housley, Greenwood, Bennett et al.: "Identification of a short form of the P2xR1-purinoceptor subunit produced by alternative splicing in the pituitary and cochlea." in: Biochemical and biophysical research communications, Vol. 212, Issue 2, pp. 501-8, 1995 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).