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Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2) (Cytoplasmic Domain) antibody

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Antigen
  • AI323649
  • BB122383
  • DFNA41
  • P2RX2
  • P2x
  • P2x2
  • P2X2
  • P2X2a
  • p2xr2
  • Pdcd3
  • RP-2
Epitope
Cytoplasmic Domain
39
15
6
6
4
3
3
2
1
1
1
Reactivity
Human
77
27
26
7
4
2
2
1
Host
Rabbit
81
6
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
80
29
21
9
8
7
Supplier
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Immunogen A synthetic peptide from the cytoplasmic domain of human P2X2 (P2RX2, P2X purinoceptor 2, Purinergic receptor, ATP receptor) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Specific for P2RX2.
Alternative Name P2RX2 (P2RX2 Antibody Abstract)
Background Function: Binding of this ligand gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: High levels in pituitary and vas deferens. Lower extent in spinal cord, bladder, brain, adrenal, testis, sensory epithelia from the inner ear. Also known as: P2RX2, P2X purinoceptor 2, Purinergic receptor, ATP receptor.
Application Notes A concentration of 10-50 mg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Scherer, Muzny, Buhay, Chen, Cree, Ding, Dugan-Rocha, Gill, Gunaratne, Harris, Hawes, Hernandez, Hodgson, Hume, Jackson, Khan, Kovar-Smith, Lewis, Lozado, Metzker, Milosavljevic, Miner, Montgomery et al.: "The finished DNA sequence of human chromosome 12. ..." in: Nature, Vol. 440, Issue 7082, pp. 346-51, 2006 (PubMed).

Lynch, Touma, Niforatos, Kage, Burgard, van Biesen, Kowaluk, Jarvis: "Molecular and functional characterization of human P2X(2) receptors." in: Molecular pharmacology, Vol. 56, Issue 6, pp. 1171-81, 1999 (PubMed).