Purinergic Receptor P2X, Lig-Nd-Gated Ion Channel, 4 (P2RX4) (cytoplasmic domain) antibody

Antigen: Purinergic Receptor P2X, Lig-Nd-Gated Ion Channel, 4 (P2RX4)

Synonyms: P2X4, P2X4R

Epitope: cytoplasmic domain

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350698

Additional Information

Alternative name: P2X4 (P2RX4, P2X purinoceptor 4, ATP receptor) (cytoplasmic domain)

Swiss-Prot: Q99571

Immunogen: A synthetic peptide from the cytoplasmic domain of human P2X4 (P2RX4, P2X purinoceptor 4, ATP receptor) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 94% identity with rat and mouse sequence.

Format: Lyophilized

Description: Function: Receptor for ATP that acts as a ligand gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Subcellular location: Membrane; Multi-pass membrane protein. Also known as: P2X4, P2RX4, P2X purinoceptor 4, ATP receptor, Purinergic receptor.

Specificity: Appears to be specific for P2RX4.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Garcia-Guzman, Soto, Gomez-Hernandez et al.: "Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue." in: Molecular pharmacology, Vol. 51, Issue 1, pp. 109-18, 1997 (PubMed).