P2X6 (P2RX6, P2X purinoceptor 6, ATP receptor, P2RXL1, P2XM) (Cytoplasmic Domain) antibody

Antigen: P2X6 (P2RX6, P2X purinoceptor 6, ATP receptor, P2RXL1, P2XM)

Binding Site: Cytoplasmic Domain

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350704

Additional Information

UniProt: O54803

Immunogen: A synthetic peptide from the cytoplasmic domain of mouse P2X6 (P2RX6, P2X purinoceptor 6, ATP receptor, P2RXL1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and shares 86% identity with human sequence.

Format: Lyophilized

Isotype: IgG

Description: Function: Receptor for ATP that acts as a ligand gated ion channel Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Expressed predominantly in skeletal muscle. Also known as: P2RX6, P2X purinoceptor 6, ATP receptor, Purinergic receptor, P2RXL1, P2XM.

Specificity: Appears to be specific for P2RX6.

Application Details

Application Notes: IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Purity: IgG

Purification: Purified mouse LPS-activated B cells

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Urano, Nishimori, Han et al.: "Cloning of P2XM, a novel human P2X receptor gene regulated by p53." in: Cancer research, Vol. 57, Issue 15, pp. 3281-7, 1997 (PubMed).

Nawa, Urano, Tokino et al.: "Cloning and characterization of the murine P2XM receptor gene." in: Journal of human genetics, Vol. 43, Issue 4, pp. 262-7, 1999 (PubMed).

Maguire, Wynne, Harney et al.: "Identification of the phosphotyrosine proteome from thrombin activated platelets." in: Proteomics, Vol. 2, Issue 6, pp. 642-8, 2002 (PubMed).

Collins, Wright, Edwards et al.: "A genome annotation-driven approach to cloning the human ORFeome." in: Genome biology, Vol. 5, Issue 10, pp. R84, 2004 (PubMed).