P2RX7 antibody (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7) (AA 40-105)

Details for Product anti-P2RX7 Antibody No. ABIN350705, Supplier: Log in to see
Antigen
  • p2xr7
  • P2RX7
  • P2X7
  • AI467586
  • P2X(7)
  • P2X7R
  • p2x7
  • purinergic receptor P2X, ligand-gated ion channel, 7
  • P2RX7
  • p2rx7
  • P2rx7
Alternatives
anti-Human P2RX7 antibody for Immunofluorescence (fixed cells)
Epitope
AA 40-105
21
16
14
4
3
3
3
2
2
2
2
2
2
1
1
1
1
Reactivity
Mouse (Murine), Human, Rat (Rattus)
90
73
36
5
4
4
4
3
3
2
2
Host
Rabbit
73
25
19
2
Clonality
Polyclonal
Conjugate
This P2RX7 antibody is un-conjugated
8
4
4
4
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
72
48
40
26
23
19
17
13
1
1
1
1
Options
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Immunogen A synthetic peptide from aa region 40-105 of mouse P2X7 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and shares 95% identity with rat's.
Specificity Specific for P2RX7.
Purification Whole serum
Alternative Name P2RX7 (P2RX7 Antibody Abstract)
Background Function: Receptor for ATP that acts as a ligand gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: P2RX7, P2X purinoceptor 7, Purinergic receptor, P2Z receptor, ATP receptor.
Research Area Neurology
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Gu, Zhang, Worthington, Sluyter, Dao-Ung, Petrou, Barden, Wiley: "A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor." in: The Journal of biological chemistry, Vol. 276, Issue 14, pp. 11135-42, 2001 (PubMed).

Buell, Talabot, Gos, Lorenz, Lai, Morris, Antonarakis: "Gene structure and chromosomal localization of the human P2X7 receptor." in: Receptors & channels, Vol. 5, Issue 6, pp. 347-54, 1999 (PubMed).

Chessell, Simon, Hibell, Michel, Barnard, Humphrey: "Cloning and functional characterisation of the mouse P2X7 receptor." in: FEBS letters, Vol. 439, Issue 1-2, pp. 26-30, 1998 (PubMed).

Rassendren, Buell, Virginio, Collo, North, Surprenant: "The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA." in: The Journal of biological chemistry, Vol. 272, Issue 9, pp. 5482-6, 1997 (PubMed).