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NGFR antibody (Nerve Growth Factor Receptor) (Cytoplasmic Domain)

Details for Product anti-NGFR Antibody No. ABIN350708, Supplier: Log in to see
Antigen
  • CD271
  • fullback
  • Gp80-LNGFR
  • LNGFR
  • ngfr
  • nrh1
  • NRH1b
  • p75
  • p75(NTR)
  • p75NGFR
  • p75NTR
  • p75ntr
  • RNNGFRR
  • tnfrsf16
  • Tnfrsf16
  • TNFRSF16
  • wu:fb38c02
  • wu:fc10h01
Alternatives
anti-Rat (Rattus) NGFR antibody for Immunocytochemistry
Epitope
Cytoplasmic Domain
23
20
15
15
9
7
7
5
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine)
254
93
81
21
21
19
18
10
7
6
6
5
1
1
1
1
1
Host
Rabbit
131
116
32
4
1
Clonality
Polyclonal
Conjugate
This NGFR antibody is un-conjugated
17
15
15
13
5
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
192
108
99
79
63
45
39
36
14
13
12
7
6
5
4
2
1
1
Supplier
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Immunogen A synthetic peptide from the cytoplasmic domain of rat p75NTR conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in mouse.
Specificity Specific for p75NTR.
Purification Whole serum
Alternative Name p75NTR (NGFR Antibody Abstract)
Background Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR.
Pathways NF-kappaB Signaling, Neurotrophin Signaling Pathway
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 200 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Vilar, Murillo-Carretero, Mira, Magnusson, Besset, Ibuaunez: "Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle." in: The EMBO journal, Vol. 25, Issue 6, pp. 1219-30, 2006 (PubMed).

Chang, Arevalo, Chao: "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein." in: Journal of neuroscience research, Vol. 78, Issue 2, pp. 186-92, 2004 (PubMed).

Kong, Boulter, Weber, Lai, Chao: "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 1, pp. 176-85, 2001 (PubMed).

Liepinsh, Ilag, Otting, Ibuaunez: "NMR structure of the death domain of the p75 neurotrophin receptor." in: The EMBO journal, Vol. 16, Issue 16, pp. 4999-5005, 1997 (PubMed).

Metsis, Timmusk, Allikmets, Saarma, Persson: "Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter." in: Gene, Vol. 121, Issue 2, pp. 247-54, 1992 (PubMed).

Radeke, Misko, Hsu, Herzenberg, Shooter: "Gene transfer and molecular cloning of the rat nerve growth factor receptor." in: Nature, Vol. 325, Issue 6105, pp. 593-7, 1987 (PubMed).