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Details for Product No. ABIN350708

p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR) (Cytoplasmic Domain) antibody

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Antigen
Epitope
»Alternatives Cytoplasmic Domain
Reactivity
»Alternatives Rat (Rattus), Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN350708
Quantity 100 ┬ÁL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the cytoplasmic domain of rat p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse.
Specificity Appears to be specific for p75NTR.
Purification Purified
Purity whole serum
Background Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR.
UniProt P07174
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Metsis, Timmusk, Allikmets et al.: "Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter." in: Gene, Vol. 121, Issue 2, pp. 247-54, 1992 (PubMed).

Radeke, Misko, Hsu et al.: "Gene transfer and molecular cloning of the rat nerve growth factor receptor." in: Nature, Vol. 325, Issue 6105, pp. 593-7, 1987 (PubMed).

Liepinsh, Ilag, Otting et al.: "NMR structure of the death domain of the p75 neurotrophin receptor." in: The EMBO journal, Vol. 16, Issue 16, pp. 4999-5005, 1997 (PubMed).

Kong, Boulter, Weber et al.: "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 1, pp. 176-85, 2001 (PubMed).

Chang, Arevalo, Chao: "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein." in: Journal of neuroscience research, Vol. 78, Issue 2, pp. 186-92, 2004 (PubMed).

Vilar, Murillo-Carretero, Mira et al.: "Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle." in: The EMBO journal, Vol. 25, Issue 6, pp. 1219-30, 2006 (PubMed).

Alternatives for antigen "p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR)", type "Antibodies"
Hosts (3)
Reactivities (1), (1), (1)
Applications (3), (3)
Epitopes (3)
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