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NGFR antibody (Nerve Growth Factor Receptor) (Cytoplasmic Domain)

Details for Product anti-NGFR Antibody No. ABIN350710, Supplier: Log in to see
Antigen
  • CD271
  • fullback
  • Gp80-LNGFR
  • LNGFR
  • ngfr
  • nrh1
  • NRH1b
  • p75
  • p75(NTR)
  • p75NGFR
  • p75NTR
  • p75ntr
  • RNNGFRR
  • tnfrsf16
  • Tnfrsf16
  • TNFRSF16
  • wu:fb38c02
  • wu:fc10h01
Alternatives
anti-Human NGFR antibody for Flow Cytometry
Epitope
Cytoplasmic Domain
23
20
15
13
9
7
7
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
247
91
80
23
21
19
18
12
9
8
6
5
2
1
1
1
1
1
Host
Rabbit
128
113
32
4
1
Clonality
Polyclonal
Conjugate
This NGFR antibody is un-conjugated
16
15
14
13
5
4
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
190
106
82
78
62
45
38
34
14
12
11
7
6
5
4
2
1
1
Supplier
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Immunogen A synthetic peptide from the cytoplasmic domain of human p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in many other species including mouse and rat.
Isotype IgG
Specificity Specific for p75NTR.
Alternative Name p75NTR (NGFR Antibody Abstract)
Background Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR.
Pathways NF-kappaB Signaling, Neurotrophin Signaling Pathway
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Mi, Lee, Shao, Thill, Ji, Relton, Levesque, Allaire, Perrin, Sands, Crowell, Cate, McCoy, Pepinsky: "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex." in: Nature neuroscience, Vol. 7, Issue 3, pp. 221-8, 2004

Wooten, Seibenhener, Mamidipudi, Diaz-Meco, Barker, Moscat: "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7709-12, 2001

Ye, Mehlen, Rabizadeh, VanArsdale, Zhang, Shin, Wang, Leo, Zapata, Hauser, Reed, Bredesen: "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30202-8, 1999

Irie, Hachiya, Rabizadeh, Maruyama, Mukai, Li, Reed, Bredesen, Sato: "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation." in: FEBS letters, Vol. 460, Issue 2, pp. 191-8, 1999

Khursigara, Orlinick, Chao: "Association of the p75 neurotrophin receptor with TRAF6." in: The Journal of biological chemistry, Vol. 274, Issue 5, pp. 2597-600, 1999

Chapman, Eckart, Kaufman, Lapointe: "O-linked oligosaccharide on the 75-kDa neurotrophin receptor." in: Journal of neurochemistry, Vol. 66, Issue 4, pp. 1707-16, 1996

Johnson, Lanahan, Buck, Sehgal, Morgan, Mercer, Bothwell, Chao: "Expression and structure of the human NGF receptor." in: Cell, Vol. 47, Issue 4, pp. 545-54, 1986