Nerve Growth Factor Receptor (NGFR) (Extracellular Domain) antibody

Details for Product No. ABIN350713
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Synonyms ngfr, wu:fb38c02, wu:fc10h01, CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, LNGFR, RNNGFRR, Tnfrsf16, p75, NRH1b, fullback, nrh1, p75ntr, tnfrsf16, p75NGFR
Extracellular Domain
(19), (14), (12), (11), (6), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Rat (Rattus)
(185), (86), (77), (8), (7), (7), (5), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
(125), (63), (30), (5), (1)
(14), (11), (8), (7), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(167), (84), (60), (55), (49), (30), (24), (24), (20), (19), (10), (7), (6), (6), (4), (4), (1), (1), (1), (1), (1), (1)
Pubmed 9 references available
Quantity 100 μL
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Catalog No. ABIN350713
454.67 $
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Immunogen A synthetic peptide from the extracellular domain of human p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR, NGFR) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in rat.
Specificity Specific for p75NTR.
Purification Whole serum
Alternative Name p75NTR
Background Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR, tumor necrosis factor receptor superfamily member 16, CD271 antigen, NGFR, TNFRSF16.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Mi, Lee, Shao et al.: "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex." in: Nature neuroscience, Vol. 7, Issue 3, pp. 221-8, 2004 (PubMed).

Bai, Chen, Huang: "RanBPM is a novel binding protein for p75NTR." in: Biochemical and biophysical research communications, Vol. 309, Issue 3, pp. 552-7, 2003 (PubMed).

Wooten, Seibenhener, Mamidipudi et al.: "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7709-12, 2001 (PubMed).

Irie, Hachiya, Rabizadeh et al.: "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation." in: FEBS letters, Vol. 460, Issue 2, pp. 191-8, 1999 (PubMed).

Ye, Mehlen, Rabizadeh et al.: "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30202-8, 1999 (PubMed).

Khursigara, Orlinick, Chao: "Association of the p75 neurotrophin receptor with TRAF6." in: The Journal of biological chemistry, Vol. 274, Issue 5, pp. 2597-600, 1999 (PubMed).

Chapman, Eckart, Kaufman et al.: "O-linked oligosaccharide on the 75-kDa neurotrophin receptor." in: Journal of neurochemistry, Vol. 66, Issue 4, pp. 1707-16, 1996 (PubMed).

Johnson, Lanahan, Buck et al.: "Expression and structure of the human NGF receptor." in: Cell, Vol. 47, Issue 4, pp. 545-54, 1986 (PubMed).

Sehgal, Patil, Chao: "A constitutive promoter directs expression of the nerve growth factor receptor gene." in: Molecular and cellular biology, Vol. 8, Issue 8, pp. 3160-7, 1989 (PubMed).

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