You are viewing an incomplete version of our website. Please click to reload the website as full version.

NGFR antibody (Nerve Growth Factor Receptor) (Extracellular Domain)

Details for Product anti-NGFR Antibody No. ABIN350714, Supplier: Log in to see
Antigen
  • CD271
  • fullback
  • Gp80-LNGFR
  • LNGFR
  • ngfr
  • nrh1
  • NRH1b
  • p75
  • p75(NTR)
  • p75NGFR
  • p75NTR
  • p75ntr
  • RNNGFRR
  • tnfrsf16
  • Tnfrsf16
  • TNFRSF16
  • wu:fb38c02
  • wu:fc10h01
Alternatives
anti-Human NGFR antibody for Flow Cytometry
Epitope
Extracellular Domain
23
20
15
15
8
7
7
5
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
253
93
82
21
21
19
18
10
7
6
6
5
1
1
1
1
1
Host
Sheep
132
116
32
4
Clonality
Polyclonal
Conjugate
This NGFR antibody is un-conjugated
17
15
15
13
5
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
192
108
99
79
63
45
39
36
14
13
12
7
6
5
4
2
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen A synthetic peptide from the extracellular domain of human p75NTR conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in rat.
Specificity Specific for p75NTR.
Purification Whole serum
Alternative Name p75NTR (NGFR Antibody Abstract)
Background Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subunit: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR, tumor necrosis factor receptor superfamily member 16, CD271 antigen, NGFR, TNFRSF16.
Pathways NF-kappaB Signaling, Neurotrophin Signaling Pathway
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Mi, Lee, Shao, Thill, Ji, Relton, Levesque, Allaire, Perrin, Sands, Crowell, Cate, McCoy, Pepinsky: "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex." in: Nature neuroscience, Vol. 7, Issue 3, pp. 221-8, 2004 (PubMed).

Bai, Chen, Huang: "RanBPM is a novel binding protein for p75NTR." in: Biochemical and biophysical research communications, Vol. 309, Issue 3, pp. 552-7, 2003 (PubMed).

Wooten, Seibenhener, Mamidipudi, Diaz-Meco, Barker, Moscat: "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7709-12, 2001 (PubMed).

Ye, Mehlen, Rabizadeh, VanArsdale, Zhang, Shin, Wang, Leo, Zapata, Hauser, Reed, Bredesen: "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30202-8, 1999 (PubMed).

Irie, Hachiya, Rabizadeh, Maruyama, Mukai, Li, Reed, Bredesen, Sato: "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation." in: FEBS letters, Vol. 460, Issue 2, pp. 191-8, 1999 (PubMed).

Khursigara, Orlinick, Chao: "Association of the p75 neurotrophin receptor with TRAF6." in: The Journal of biological chemistry, Vol. 274, Issue 5, pp. 2597-600, 1999 (PubMed).

Chapman, Eckart, Kaufman, Lapointe: "O-linked oligosaccharide on the 75-kDa neurotrophin receptor." in: Journal of neurochemistry, Vol. 66, Issue 4, pp. 1707-16, 1996 (PubMed).

Sehgal, Patil, Chao: "A constitutive promoter directs expression of the nerve growth factor receptor gene." in: Molecular and cellular biology, Vol. 8, Issue 8, pp. 3160-7, 1989 (PubMed).

Johnson, Lanahan, Buck, Sehgal, Morgan, Mercer, Bothwell, Chao: "Expression and structure of the human NGF receptor." in: Cell, Vol. 47, Issue 4, pp. 545-54, 1986 (PubMed).