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Painless (PAIN) (Extracellular Loop) antibody

Details for Product No. ABIN350716
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Antigen
Synonyms CG15860, CT31987, Dmel\\CG15860, EP2251, Pain, GLEAN_07561, GB10136, NV14270
Epitope
Extracellular Loop
(1)
Reactivity
Mouse (Murine)
(1), (1), (1)
Host
Rabbit
(1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(1), (1)
Pubmed 2 references available
Quantity 100 µL
Options
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Catalog No. ABIN350716
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from 3d extracellular loop of drosophila Pain conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for 5HT5A receptor.
Purification Purified
whole serum
Alternative Name Pain (Transient receptor potential cation channel protein painless)
Background Function: Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Present in multidendritic neurons, chordotonal neurons, a subset of cells in the central nervous system and a subset of sensory neurons in the antennal-maxillary complex. Not detected in gonads and dorsal vessels (at protein level). Expressed in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors.
Developmental stage: Expressed from stage 13 of embryonic development in a small number of cells in the central nervous system and in a subset of neurons of the peripheral nervous system. Such cells may include sensory precursors of multidendritic (md) neurons. At embryonic stage 16, prior to when dendritic process are elaborated, it appears to be expressed in multidendritic neurons in a polarized manner. At stage 17 of development, when the md neurons first initiate dendritogenesis, it is localized to branched projections initiating from clusters of multidendritic neurons. Also known as: Transient receptor potential cation channel protein painless.
UniProt P35364
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Adams, Celniker, Holt et al.: "The genome sequence of Drosophila melanogaster." in: Science (New York, N.Y.), Vol. 287, Issue 5461, pp. 2185-95, 2000 (PubMed).

Tracey, Wilson, Laurent et al.: "painless, a Drosophila gene essential for nociception." in: Cell, Vol. 113, Issue 2, pp. 261-73, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350716
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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