Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN350717

Painless (PAIN) (4th Cytoplasmic Loop) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms CG15860, CT31987, Dmel\\CG15860, EP2251, Pain, GLEAN_07561, GB10136, NV14270
Epitope
»Alternatives 4th Cytoplasmic Loop
Reactivity
»Alternatives Mouse (Murine), Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN350717
Quantity 1000 µg
Price
454.67 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from 4th cytoplasmic loop of drosophila Pain (Transient receptor potential cation channel protein painless) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for Desmin.
Purification Purified
Purity whole serum
Alternative Name Pain (Transient receptor potential cation channel protein painless)
Background Function: Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Present in multidendritic neurons, chordotonal neurons, a subset of cells in the central nervous system and a subset of sensory neurons in the antennal-maxillary complex. Not detected in gonads and dorsal vessels (at protein level). Expressed in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors.
Developmental stage: Expressed from stage 13 of embryonic development in a small number of cells in the central nervous system and in a subset of neurons of the peripheral nervous system. Such cells may include sensory precursors of multidendritic (md) neurons. At embryonic stage 16, prior to when dendritic process are elaborated, it appears to be expressed in multidendritic neurons in a polarized manner. At stage 17 of development, when the md neurons first initiate dendritogenesis, it is localized to branched projections initiating from clusters of multidendritic neurons. Also known as: Transient receptor potential cation channel protein painless.
UniProt P48675
Research Area Cancer, Cytoskeleton
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in othr applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 1000 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Adams, Celniker, Holt et al.: "The genome sequence of Drosophila melanogaster." in: Science (New York, N.Y.), Vol. 287, Issue 5461, pp. 2185-95, 2000 (PubMed).

Tracey, Wilson, Laurent et al.: "painless, a Drosophila gene essential for nociception." in: Cell, Vol. 113, Issue 2, pp. 261-73, 2003 (PubMed).

Alternatives for antigen "Painless (PAIN)", type "Antibodies"
Hosts (1)
Reactivities (1)
Applications (1), (1)
Epitopes (1)
Beacon