Paraneoplastic Antigen MA2 (PNMA2) (C-Term) antibody

Antigen: Paraneoplastic Antigen MA2 (PNMA2)

Synonyms: MA2, MM2, RGAG2, KIAA0883, PNMA2, mKIAA0883, A830049P17Rik, MGC137318, DKFZp459C042

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350724

Additional Information

Alternative name: Paraneoplastic antigen Ma2 (c-terminal region)

Swiss-Prot: Q9UL42

Immunogen: A synthetic peptide from c-terminal region of human Paraneoplastic antigen Ma2 conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: SUBCELLULAR LOCATION: Nucleus › nucleolus. Tissue specificity: Brain specific. In some patients suffering from cancers, it is also specifically expressed by the testicular tumor cells. Also known as: Onconeuronal antigen Ma2, Paraneoplastic neuronal antigen MM2, 40 kDa neuronal protein, PNMA2, MA2.

Specificity: Appears to be specific for PNMA2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Nagase, Ishikawa, Suyama et al.: "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 6, pp. 355-64, 1999 (PubMed).

Dalmau, Gultekin, Voltz et al.: "Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders." in: Brain : a journal of neurology, Vol. 122 ( Pt 1), pp. 27-39, 1999 (PubMed).

Voltz, Gultekin, Rosenfeld et al.: "A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer." in: The New England journal of medicine, Vol. 340, Issue 23, pp. 1788-95, 1999 (PubMed).

Rosenfeld, Eichen, Wade et al.: "Molecular and clinical diversity in paraneoplastic immunity to Ma proteins." in: Annals of neurology, Vol. 50, Issue 3, pp. 339-48, 2001 (PubMed).