Peropsin (RRH) antibody

Antigen: Peropsin (RRH)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350728

Additional Information

Alternative name: peropsin (retinal pigment epithelium derived rhodopsin homolog, OPSX, RRH)

Swiss-Prot: O14718

Immunogen: A synthetic peptide from human peropsin (retinal pigment epithelium derived rhodopsin homolog, OPSX, RRH) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes opsin 5 and retinal G protein coupled receptor. FUNCTION: May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments. Also known as: RRH, visual pigment-like receptor peropsin.

Specificity: Appears to be specific for OPSX.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Sun, Gilbert, Copeland et al.: "Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 18, pp. 9893-8, 1997 (PubMed).

Bellingham, Wells, Foster: "In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution." in: BMC genomics, Vol. 4, Issue 1, pp. 3, 2003 (PubMed).