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Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) (pTyr820) antibody

Details for Product No. ABIN350738
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Antigen
Synonyms TRKC, gp145(trkC), AW125844, Ntrk3_tv3, TrkC, trkC
Epitope
pTyr820
(20), (11), (9), (7), (5), (5), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Human
(96), (53), (46), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(68), (30), (8), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(91), (46), (38), (16), (14), (14), (4), (3), (1), (1), (1)
Pubmed 8 references available
Quantity 100 µL
Options
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Catalog No. ABIN350738
454.67 $
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Immunogen A synthetic peptide to phospho Y820 of human TrkC conjugated to blue carrier protein was used as the antigen. The antigen is homologous in rat and mouse.
Specificity Specific for TrkC.
Purification Whole serum
Alternative Name TrkC
Target Type Tag
Background Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein.
Tissue specificity: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. Also known as: Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3.
Research Area Cancer
Application Notes A dilution of 1 : 300 to 1 : 3000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications. This antibody may also recognise the unphosphorylated form.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
anti-Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) (pTyr820) antibody WB on rat brain lysate using Rabbit antibody to phospho Y820 TrkC (Trk-C, NTRK3, NT-3 growth factor receptor, GP145-TrkC): whole serum (ABIN350738) at 1 : 1000 dilution incubated overnight at 4°C. A single band will be detected. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band.
General Merlio, Ernfors, Jaber et al.: "Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system." in: Neuroscience, Vol. 51, Issue 3, pp. 513-32, 1993 (PubMed).

McGregor, Baylin, Griffin et al.: "Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant." in: Genomics, Vol. 22, Issue 2, pp. 267-72, 1995 (PubMed).

Shelton, Sutherland, Gripp et al.: "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 2, pp. 477-91, 1995 (PubMed).

Valenzuela, Maisonpierre, Glass et al.: "Alternative forms of rat TrkC with different functional capabilities." in: Neuron, Vol. 10, Issue 5, pp. 963-74, 1993 (PubMed).

Tsoulfas, Soppet, Escandon et al.: "The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells." in: Neuron, Vol. 10, Issue 5, pp. 975-90, 1993 (PubMed).

Qian, Riccio, Zhang et al.: "Identification and characterization of novel substrates of Trk receptors in developing neurons." in: Neuron, Vol. 21, Issue 5, pp. 1017-29, 1999 (PubMed).

Ultsch, Wiesmann, Simmons et al.: "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC." in: Journal of molecular biology, Vol. 290, Issue 1, pp. 149-59, 1999 (PubMed).

Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Validation Images
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